Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2012, Vol. 39 ›› Issue (5): 514-517.

• 综述 • Previous Articles     Next Articles

Application of Gonadotrophin-Releasing Hormone Analogs in Malignant Gynecological Neoplasms

LIU Shi-ping，YANG Jia-xin   

  1. Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Science & Peking Union Medical College，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-10-15 Online:2012-10-15
  • Contact: YANG Jia-xin

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Abstract: According to its mechanisms of action，gonadotrophin-releasing hormone analogs　（GnRH-A）　are divided into two categories：agonist and antagonist． It has been demonstrated that 80% of ovarian and endometrial cancers express GnRH and its receptors． The anti-cancer role of GnRH-A is played either by suppressing the hypothalamic-pituitary axis or through its autocrine and paracrine systems． GnRH-A had been used in the treatment of advanced or recurrent endometrial and ovarian cancers，but the effect is no better than other second-line drugs．These days，the application of GnRH-A in the preservation of fertility and ovarian function has become increasingly popular． Besides，the use of GnRH-A in molecular targeted therapy is also promising.

Key words: Gonadotropin-releasing hormone, Receptors, LHRH, Genital neoplasms, female, Therapy