Abstract: Advanced glycation end products（AGEs） are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of macromolecules such as proteins， lipoproteins and nucleic acids. AGEs can directly lead to cell damage， but also can play a biological effect by binding to the receptor. Studies have shown that AGEs had a closely relationship with mitochondrial oxidative stress damage and lipid metabolism disorders. Pre-eclampsia， a hypertensive disorder which occurs only during pregnancy， is a major cause of maternal-fetal morbidity and mortality. However， the mechanisms responsible for the pathogenesis of pre-eclampsia are not completely understood. It is generally agreed that mitochondrial oxidative stress damage and lipid metabolism disorders are involved in the pathogenesis of preeclampsia. This article reviews the role of AGEs in preeclampsia.

Key words: Pre-eclampsia, Oxidative stress, DNA, mitochondrial, Advanced glycation end products