Abstract: Endometriosis is a common benign gynecologic disease, which causes pelvic pain and infertility, but the pathogenesis is unknown at present. CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity.Transcription factors Foxp3 expression on CD4+CD25+ regulatory T cells specifically, which can be used as a specific symbol of regulatory T cells. Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function. The role of regulatory T cells in endometriosis has been paid attention to. In this review，we focus on the relevance between the expression of Foxp3 and the pathogeny of endometriosis.

Key words: Endometriosis, Transcription factors, CD4-positive T-lymphocytes, T-lymphocytes, Infertility, female