Abstract: Objective：Exploring the feasibility and safety of the joint epidural anesthesia by the ProSeal laryngeal mask （the third generation esophageal drainage type laryngeal mask air duct，PLMA） in the geriatric laparoscopic gynecological operation. Methods：Dividing equally 100 cases patients at the age of 60-85 and with ASA grades of Ⅱ-Ⅳ at random into the group of ProSeal laryngeal mask joint epidural anesthesia（Group P，50 cases）and the group of tracheal intubation （Group T，50 cases）. Recording the MAP and HR of both groups of patients at the time of their entrance into the operating room（T0），before the induced tube placement（T1），at the moment of inserting the laryngeal mask/tracheal intubation（T2），5 minute of inserting the laryngeal mask/tracheal intubation（T3），in the maintaining period of anesthesia for operation（T4） and immediately after pulling out the laryngeal mask/tracheal catheter（T5）；5 minute before and after pneumoperitoneum，the Ppeak and PET（CO2） of both groups；the change in the blood gas analysis 5 minute before and after pneumoperitoneum of both groups；as well as the levels of AE，NE and DA detected by using high performance liquid chromatography and liquid chromatography analyser at T0，T1，T2，T3，T4 and T5，two groups of patients after surgery to awakening to time，and also the relevant complications of the patients. Results：The MAP and HR of two groups at T1 are lower than T0 （P＜0.05）. The MAP and HR of Group T at T2，T5 are significantly higher than those of Group P （P＜0.05）. The AE，NE and DA of two groups at T2，T5 are significantly rise （P＜0.05）. The AE，NE and DA of Group T at T2，T5 are significantly higher than those of Group P （P＜0.05）. The changes in IPPV of Ppeak，PET（CO2）、pH、Pa（O2） and Pa（CO2） are no difference between the two groups（P＞0.05）. The awakening time of Group P are significantly shorter than those of Group T （P＜0.05）. The complications in Group P are significantly fewer than those in Group T（P＜0.05）. Conclusions：The use of the PLMA joint anesthesia in the geriatric laparoscopic gynecologic operation is better than the tracheal intubation joint anesthesia，with positive features of being safe，stablied haemodynamics，slight fight-or-flight response，awakening time is short and less complications and is easy to operate，so it deserves wide application.

Key words: Laryngeal masks, Intubation, intratracheal, Aged, Laparoscopes, Gynecologic surgical procedures, PLMA