Abstract: Telomeres are located at the ends of eukaryotic chromosomes DNA repeat sequence. The capacity of cell proliferation will gradully lose result from telomeres deletion and result in cellular senescence and death. Telomerase has the ability to catalyze the synthesis of telomeric DNA, which can help maintain telomere in length. Human telomerase catalytic subunit (hTERT) can activate telomerase activity, extend the ends of chromosomes DNA, maintain the stability and integrity of the genome thus to extend the cell ageing. Studies have confirmed the existence of a close relationship among estrogen, telomeres, telomerase and body aging, and estrogen can activate telomerase through various mechanisms to delay aging and influence the promoter activity of hTERT. In this paper, the mechanism of estrogen regulated telomerase activity anti-ageing were been summarized.

Key words: Estrogens, Telomere, Telomerase, Catalytic domain, Aging