Abstract: Objective：To investigate the relationship between antithyroid antibodies（ATA） and recurrent spontaneous abortion（RSA）. Methods：Collected the women undergoing the examinations before pregnancy in out-patient department from August 2013 to March 2014，and according with the criterion had made for the study. 92 women had RSA history were in the study group，and their chromosome and coagulation function tests were normal. 226 women without RSA history were in the control group. TgAb(+) and/or TPOAb(+) suggested ATA(+)。Results：① In study group，the position rate of ATA in 35 years old and above women and younger than 35 years old was 39.29%（11/28） and 26.56%（17/64） respectively. There was no statistical significance（P＞0.05）. And in control group was 25.00%（10/40） and 18.28%（34/186） respectively, no statistical significance（P＞0.05）. So we thought ATA positive rate in different age stage was similar.② ATA positive rate was 30.43%（28/92） in study group，higher than the control′s 19.47%（44/226），the difference had statistical significance（P＜0.05）. TPOAb positive rate in study and control group was 30.43%（28/92） and 11.95%（27/226），the difference had statistical significance（P＜0.05）. TgAb positive rate was 7.61%（7/92）in the study group，although it was higher than the control 7.52%（17/226），but no statistical significance（P＞0.05）. Conclusions：ATA was related with RSA significantly, especially TPOAb.

Key words: Abortion, habitual, Thyroglobulin, Iodide peroxidase, Anti-thyroid antibody