Abstract: Objective：To study the clinical presentation，pathological features，treatment and prognosis of primary malignant melanoma（MM） of the uterine cervix. Methods：The clinical and pathological date of four patients with primary cervical MM of PLA General Hospital from 2002 to 2012 were analyzed retrospectively. Their follow-up records were all reviewed. Results： One patient of primary cervical MM were diagnosed FIGO stageⅠb1，one was FIGO stage Ⅱa, two patients was FIGO Stage Ⅲa. S-100 protein and HMB45 were positive in the four patients. Vimentin was positive in three of the patients. Melan-A was positive in two of the patients. The four patients all underwent surgical treatment. Two of them used chemotherapy and one used radiation as postoperative adjuvant therapy. One patient died 6 months and one died 40 months for metastasis. One patient died 25 months because of recurrence. One patient has survived for 34 months until now without metastasis and recurrence . Conclusions：Primary cervical MM is a extremely rare neoplasm with poor prognosis. The diagnosis is confirmed by histological examination and immunohistochemical study with exclusion of other sites of melanoma. Standardized treatment is not well established to date. The most popular treatment mode appears to be radical hysterectomy.

Key words: Malignant melanoma, Cervix, Immunohistochemistry