Abstract: Objective：To investigate the affection of hemodynamic changes to pregnancy results in women suffer from severe preeclampsia or/combined with intrahepatic cholestasis by noninvasive hemodynamic monitoring system. Methods：176 pregnant women were selected and classified into following groups: severe ICP （n=32）, severe preeclampsia （PE, n=81）, severe PE combined with ICP （n=25）, normal control （n=38）. Noninvasive hemodynamic monitoring, cardiac color ultrasonography monitoring, biochemical testing, and delivery information collecting were performed in all patients. Results：FGR and IUFD rates of PE combined with ICP group were the highest （P＜0.05）, and the apgar score （0 min） was the lowest （P＜0.05）. Furthermore, the peripheral vascular resistance, blood viscosity, cardiac index （CI）, stroke index and the peripheral vascular compliance change most distinct in all the hemodynamic index （P＜0.05）, the left atrial diameter （ＬＡ） and left ventricular end diastolic diameter （LVD） were increased, left ventricular ejection fraction （ＥＦ） was the lowest. In severe ICP group, blood viscosity and peripheral arterial compliance were also significantly varied （P＜0.05）. However, CI, heart beat index, peripheral vascular resistance, LA, LVD, and EF average value did not obviously vary （P＞0.05）. Otherwise, the increase of blood viscosity in pregnant women was closely related to FGR（OR=2.973，95%CI：2.047-4.319，P＜0.05）. Conclusions：Noninvasive hemodynamic monitoring system combined with biochemical testing provides another way to monitor the fetal intrauterine hypoxia, and reduce the rate of intrauterine fetal death.

Key words: Pre-eclampsia, Cholestasis, intrahepatic, Fetal growth retardation, Hemorheology, Blood viscosity