Abstract: Objective：To evaluate the effectiveness and safety of different treatments in stage ⅡB cervical cancer. Methods：Databases including PubMed, EMBase, Medline, The Cochrane Library（Issue 12, 2014）, CBM, CNKI, VIP and WanFang Data were search. According to the inclusion and exclusion criteria, two reviewers identified literature, extracted data and assessed quality independently. Then meta-analysis was performed using RevMan 5.3 software. Results：Three RCTs, one prospective trials, seventeen case-control studies involving 2 486 patients were included. NACT group compared with RS group, survival has not yet found statistically significant difference, the intraoperative blood loss, operation time, lymph node metastasis rate and postoperative complications of the former is lower than the latter. The 5-years OS and the incidencerate of radioactive cystitis are not statistical differences between multimodality therapy of surgery and concurrent chemoradiation. The incidence rate of radioactive cystitis of the former is less than the latter. The multimodality therapy of surgery compared with radiotherapy, there are no statistical differences in 3-year OS and the rate of fistula formation, but the 5-year OS of the former higher than the latter, the rate of radioactive enteritis of the former is lower than the latter. The gastrointestinal reaction′s rate and hematological toxicity′s rate are lower in the radiotherapy alone group than the concurrent chemoradiation group. Conclusions：The multimodality therapy of surgery treatment of stage ⅡB cervical cancer is the most effective treatment. Compared with RS, itcould reduce the intraoperative blood loss, operation time, lymph node metastasis rate and postoperative complications. Adverse reaction rate is lower than radiotherapy or concurrent chemoradiation. Therefore the multimodality therapy of surgery is more beneficial to improve the quality of life after treatment.

Key words: Evidence-based medicine, Meta-analysis, Uterine cervical neoplasms, Carcinoma, Therapy