Abstract: Pregnancy complicated with diabetes have two cases, one kind is based on the original diabetes merging pregnancy, namely pregestational diabetes mellitus, the other is diabetes occur first time during pregnancy, namely gestational diabetes mellitus (GDM). Pregnancy with diabetes have threat to pregnancy outcome. Obesity plays an important role in occurrence and development of pregnancy with diabetes, but physical exercise can improve the condition of pregnancy with diabetes by reducing obesity. In recent years, researchers found that Irisin appears to contribute to the benefits of exercise to metabolic homeostasis. Irisin is a kind of muscle factor produced by skeletal muscle movements, it can roled in a variety of target organs of glucolipid metabolism, such as fat, liver and pancreatic islet cells. Studies have shown that in patients with obesity, diabetes or GDM, Iirisin may have consequences on lipid, glucose and energy metabolism, insulin resistance and insulin secretion capacity. Irisin can promote the burning of fat cells, inhibit gluconeogenesis and increase the islet cells regeneration. Irisin may be related to the occurrence and development of pregnancy complicated with diabetes. By improving the obesity and reducing insulin resistance, Irisin is expected to become a target in prevention and treatment of obesity related metabolic diseases.

Key words: Irisin, Obesity, Diabetes mellitus，type 2, Diabetes，gestational, Exercise therapy