Abstract: Objective: To explore the curative effect of GnRHa combined with levonorgestrel-releasing intrauterine system（ＬＮＧ－ＩＵＳ） in the treatment of severe large uterine adenomyosis. Methods：A total of 42 cases of severe uterine adenomyosis were divided into two groups randomly, the treatment group and the control group, with 21 cases in each group. The treatment group were inserted LNG-IUS following 4 cycles of treatment by GnRHa and the control group were treated only by 4 cycles of GnRHa. Six months after placement of LNG-IUS, uterine size, menstrual quantity and degree of dysmenorrhea were compared between the two groups. Follow-up was taken at the following time points: before the injection of GnRHa （Ｔ０）, immediately after the injection of GnRHa （Ｔ１）, 3 months （Ｔ３）, 6 months （Ｔ６）, 9 months （Ｔ９）, 12 months （Ｔ１２） after the injection of GnRHa. Also the size of uterus, menstrual quantity and degree of dysmenorrhea were recorded during the follow-up. Results：The size of uterus, menstrual quantity and degree of dysmenorrheal in the treatment group at T3, T6, T9, T12 were significantly decreased than that in the control group （P＜0.05）. Compared with that at T0, the size of uterus at T1, menstrual quantity and degree of dysmenorrheal in the control group at T3 were significantly decreased （P＜0.05）. But there was no significantly difference in the size of uterus, menstrual quantity and degree of dysmenorrheal between the control group at T6, T9 and T12 and the control group at T0. The size of uterus at T1, menstrual quantity and degree of dysmenorrheal in the treatment group at T3, T6, T9, T12 were significantly decreased than that at T0 （Ｐ＜０．０５）. Conclusions：Compared with the sole injection of CnRHa, GnRHa combined with LNG-IUS is more effective for a short term in the treatment of severe uterine adenomyosis and relief of clinical symptoms.

Key words: Uterine diseases, Endometriosis, Gonadotropin-releasing hormone, Levonorgestrel, Intrauterine devices，medicated