Abstract: Objective: Using human trophoblast HTR-8/SVneo (HTR) cell lines for the study of the carrier to study Schisandrin B (Sch B)′s action of benzo[a]pyrene (BaP) damage effect on HTR cell lines aggressivity. Methods：Experiment is divided into the control group, the BaP infected group, different dose Sch B (0.5, 1, 2 μmol/L), intervention infected groupcell proliferation by MTS experimental detection, clear BaP canister and Sch B intervention dose, by Transwell invasion experiment after the detection of BaP infected cells and Sch B cell invasion force change after intervention. Results：①The MTS test cell proliferation,compared with control group, 20 μmol/L BaP concentration cell proliferation significantly decreased after effect （P＜0.01）, after Sch B （0.5, 1, 2 μmol/L） intervention the cell proliferation is obviously better than BaP infected group（P＜0.05）. ②Transwell cell invasion experiment, compared with control group, the BaP cells infected group was much less aggressive （P＜0.05）. Sch B intervention group cell invasion force also declined （P＜0.05）. Compared with the infected group, Sch B cells of aggressive intervention group was obviously ascending （Ｐ＜０．０５）. Conclusions：①A certain concentrations of BaP damaged HTR cell proliferation and invasion force. ②Sch B can prevent the damage of BaP of HTR cell proliferation, and at the same time improve cell aggressivity.

Key words: Schisandra, Benzo(a)pyrene, Cell proliferation, Trophoblast cell