Abstract: High risk human papillomavirus (HR-HPV) persistent infection is the major cause of cervical intraepithelial neoplasia(CIN) and cervical cancer. Women after standard treatment for high-grade CIN(HG-CIN) are at higher risk of subsequent disease compared to the general population. After treatment, HR-HPV positive, cytological abnormalities, positive margins were the predictors of residual/recurrent disease after treatment of cervical high-grade lesions. HPV genotyping can be used to identify the different infection status of HR-HPV after treatment, which is helpful for detecting the high-risk groups. The persistent infection of the same type HR-HPV was closely associated with the residual lesions or recurrence after treatment of HG-CIN compared with the HR-HPV new infection or recurrent infection. HPV16/18 is the most common type of persistent infection in patients with HG-CIN, which has a higher risk of residual lesions or recurrent disease and need to closely follow-up. HPV genotyping increases sensitivity for the detection of residual or recurrent disease after treatment for HG-CIN than cytology and HR-HPV testing, remains equal or better sensitivity.

Key words: Papillomaviridae, Genes, Cervical intraepithelial neoplasia, Follow-up studies, Neoplasm, residual, Recurrence