Abstract: Objective：To assess the association between single nucleotide polymorphism (SNP) of endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and hypertensive disease complicating pregnancy (HDCP) in ethnic Han Chinese in Huai′an area. Methods：100 Han Chinese with HDCP and 310 normal controls were enrolled． Genotypes of rs2549782 within ERAP2 gene was determined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Results：Distribution of G and T allele showed no significant difference between the two groups (P=0.089), but the distributions of genotypes presented statistically significant difference (P=0.045). After adjusted for confounding factors, results from logistic regression analysis indicated that G allele, GT and GG genotype were risk factors for HDCP in Huai′an women population (OR=1.64, 95%CI: 1.09-2.47; OR=2.23, 95%CI: 1.01-4.07; OR=2.96, 95%CI: 1.20-7.31). Conclusions：This study suggested that rs2549782 polymorphism of the ERAP2 gene might be associated with GH in ethnic Han Chinese from Huai′an area, the G allele, GT and GG genotype might increase the risk for HDCP.

Key words: AminopeptidasesHypertension, pregnancy-induced, Polymorphism, single nucleotide, Endoplasmic reticulum aminopeptidase 2 gene