Abstract: The three common malignant tumors of female reproductive system are cervical cancer, endometrial cancer, ovarian cancer, which are threatening the health of women. With continuous economical development of society, the pace of life is accelerating and the incidence rate of malignant diseases is increasing year by year. Eukaryotic initiation factor 4E (eIF4E) is one of the factors closely related to the occurrence and development of malignant tumors. It may specifically bind to the cap structure of mRNA 5′end and play an important role in the initiation of transcription, translation and mRNA production in cell nucleolus and cell proliferation. eIF4E activity regulated by factors such as the phosphorylation, the phosphorylation of translation inhibitory protein. The study founds that eIF4E is highly expressed in gynecologic malignancies can be expected as a new targeted biotherapy of gynecological malignant tumors, which assists in the diagnosis, early prevention and treatment of diseases.
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Key words: Eukaryotic initiation factor-4E, Genital neoplasms, female, Gene expression regulation, Antineoplastic protocols