Abstract: Preeclampsia (PE) is an idiopathic hypertension syndrome that occur after 20th week of gestation, whose etiology and pathogenesis have not yet been completely elucidated. Long non-coding RNA (lncRNA) is classified as RNA greater than 200 nucleotides in length that do not produce a protein product. LncRNAs are expressed with cellular and temporal specificity and have been shown to play a role in many cellular events, including the regulation of gene expression, post-transcriptional modifications and epigenetic modifications. In the current study, expressions of lncRNA were abnormal in PE placenta. It was speculated that lncRNA may affect the growth and reproduction of placenta and play an important role in the pathogenesis of PE, therefore further study of PE-related lncRNA and its regulatory mechanism may be helpful to elucidate the pathogenesis of PE and provide new ideas for PE prevention and treatment. Here, we review the current literature surrounding the lncRNAs related to PE.

Key words: Pre-eclampsia, HELLP syndrome, Long non-coding RNA, Trophoblast cell