Research Progress of COX-2, E-cadherin and PPAR-γ in Pre-eclampsia

Abstract

Abstract: Pre-eclampsia (PE) is a specific disease of pregnancy, which seriously affects the health and safety of pregnant women and perinatal infants. The pathogenesis of PE is not yet clear. Cyclooxygenase-2(COX-2) is an important inducible isoenzyme in the inflammatory response. Its prostaglandin is an important inflammatory mediator. E-cadherin has the function of promoting mutual among cells，and it is a potential marker for identifying cell trophoblast cells. Peroxisome proliferator-activated receptor-γ(PPAR-γ) is involved in various physiological and pathological processes after ligand activation. In addition, COX-2 is associated with E-cadherin and PPAR-γ in the development of certain diseases, respectively. COX-2, E-cadherin and PPAR-γ are closely related to the onset of PE. The in-depth study of three factors can provide more clues for the pathogenesis of PE, thus providing new directions and ideas for the prediction, prevention and treatment of the disease.

Key words: Pre-eclampsia, Prostaglandin-endoperoxide synthases, Cadherins, PPAR gamma

ZHANG Na-na, WANG Chen-hong. Research Progress of COX-2, E-cadherin and PPAR-γ in Pre-eclampsia[J]. Journal of International Obstetrics and Gynecology, 2018, 45(5): 541-543.

References

[1]Mol BWJ, Roberts CT, Thanqaratinam S, et al. Pre-eclampsia[J]. Lancet,2016,387(10022):999-1011. [2]Hannan NJ,?Binder NK,?Beard S, et al. Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia[J].PLoS ONE, 2018, 13(4): e0187082. [3]谢幸，苟文丽. 妇产科学[M].北京：人民卫生出版社，2013:64-71. [4]Teddi Bachawaty, Sonya L. Washington, Scott W. Walsh. Neutrophil Expression of Cyclooxygenase-2 in Preeclampsia[J]. Reprod Sci, 2010 ,17(5): 465-470. [5]T. Groten, N. Gebhard , R. Kreienberg ,et al. Differential expression of VE-cadherin and VEGFR2 in placental syncytiotrophoblast during preeclampsia-New perspectives to explain the pathophysiology[J]. Placenta, 2010, 31:339-343. [6]Ying Wu, Yan Ruan,Lin Shen,et al. Protective effects of PPAR-γ against pregnancy-induced hypertension by differential ETR expression in rat models[J]. J Cell Biochem. 2018,119:3118-3128. [7]欧阳艳琼，陈汉平，沈红玲.环氧合酶-2在子痫前期患者胎盘组织中的表达[J].中国优生与遗传杂志，2007,15（4）:38-40. [8]杨艳峰，刘锡梅，罗霞，等.COX-1,COX-2在子痫前期患者胎盘和脐带组织的表达[J].现代妇产科进展，2009,18（3）:212-215. [9]陈丽红，邱中原，胡继芬. 子痫前期患者胎盘中 p38MAPK 及COX-2 的表达及意义[J]. 第三军医大学学报，2012，34(6):521． [10]Goksu Erol AY, Nazli M, Yildiz SE. Expression levels of cyclooxy-genase-2, tumor necrosis factor-alpha and inducible NO synthase inplacental tissue of normal and preeclamptic pregnancies[J]. J Matern Fetal Neonatal Med, 2012, 25(6):826-830． [11]庄旭，叶太阳，林建华. 子痫前期易感基因研究进展与展望[J].实用妇产科杂志，2014,30（9）:664-667. [12]Gurdol F,?Cakmakoglu B,?Dasdemir S,?Isbilen E, et al. -765 G→C and -1195 A→G promoter variants of the?cyclooxygenase-2?gene decrease the risk for?preeclampsia[J]. Genet Test Mol Biomarkers,?2012, May,16(5):435-8. [13]Bilban M, Tauber S, Haslinger P, et al.Trophobiast invasion: assessement of cellular models using gene expression signature[J]. Placenta, 2010, 31(11):989-996. [14]Lau MT，K lausen C，Leung PC et al. E- cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin - Egrl - mediated PTEN expression[J]. Oncogene,2011,30 (24): 1753. [15]Pollheimer J, Knofler M．The role of the invasive，placental trophoblast in human pregnancy[J]. Wien Med Wochenschr, 2012, 162(9-10): 187-190. [16]Shin ieM, Hsu MY, Oldt RJ, et al. The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast[J]. Placenta, 2002, 23 (10): 706-715． [17]L. M. Brown, H. AL. Lacey, P. N. and I. P. Crocker. E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre- eclampsia[J]. Histochemistry and Cell Biolology, 2005, 124 (6): 499. [18]Heazell AE, Taylor NN, Greenwood SL, et al. Does altered oxy-genation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells[J]. Reprod Biomed Online, 2009, 18( 1) :111-119. [19]赵莹，李小姝，崔金全.子痫前期患者E- 钙黏蛋白的表达及意义[J]. 中国妇幼保健, 2013,28(19):3153-3156. [20]Li LC,Chui RM, Sasaki M, et al. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities[J]. Cancer Res, 2000,60(4):873-876. [21]Y Barak, MC Nelson, ES Ong, et al. PPAR gamma is required for placental, cardiac,and adipose tissue development[J]. Molecular Cell,?1999,?4(4):585-595. [22] Lebovic DI, Kit M, Casey C L. P eroxisome proliferators-activated receptor- garmna induces regression of endometrial explants in a rat model of endometriosis[J]. Fertil Stefil, 2004,82(3) :1008-1013. [23]李淑娟，常子强，尚涛，等．Ⅱ型核受体 PPARγ 和金属蛋白酶MMP-2、MMP-9在早孕胎盘组织中的表达及意义[J]．生殖与避孕，2008，7：409 -414． [24]张扬，邹晓泽，张双月，等. 过氧化物酶增殖物活化受γC161→T基因多态性与原发性高血压相关性研究[J]．中华实用诊断与治疗杂志，2014,28（2）:134-136. [25]Gang Wang, Ping Xu, Wei Feng, et al. Case-control study on peroxisome proliferator-activated receptor gamma polymorphism and interaction[J]．Iranian Journal of Basic Medical Sciences, 2015,18?(12)?:1228-1232. [26]赵莹. E–cadherin和 COX-2在子痫前期患者胎盘中的表达[D]．郑州大学，2013. [27]Cui Y, Miyoahi K, Claudio E, et a1. Loss of the peroxisome proliferation-activated receptor gamma does not affect mammary development and propensity for tum or form ation but leads to reduced fertif ity[J]．Biological Chemistry, 2002, 277:17830 -17835． [28]于恩燕.子痫前期胎盘组织中PPAR-γ与COX-2的表达及临床意义[D]．山东大学，2010.