Effect of Intensity-Modulated Radiotherapy Combined with Chemotherapy on Oncogene in Patients with Endometrial Carcinoma

Abstract

Abstract: Objective：To explore the effect of intensity modulated radiation therapy (IMRT) combined with chemotherapy on endometrial cancer and on the expression of oncogene in the patients. Methods: A total of 100 patients with endometrial cancer who were treated in the Tumor Hospital Affiliated to Zhengzhou University from January 2017 to January 2018 were randomly divided into chemotherapy group and combined group, 50 cases in each group. The chemotherapy group was treated with paclitaxel plus platinum (TC) chemotherapy regimen, and the combined group was treated with intensity modulated radiotherapy (IMRT) based on the chemotherapy group. The quality of life of the two groups was scored before and after treatment; the therapeutic effects of the two groups were compared, and the proto-oncogenes c-erbB2, c-myc, K-ras and tumor suppressor genes P53, P16 and PTEN were detected by real-time fluorescence quantitative RT-PCR. The incidence of adverse reactions in the two groups during treatment was counted. Results: There was no significant difference in the scores of life function between the two groups before treatment (P＞0.05); after treatment, the scores of life function of the two groups were higher than those before treatment, and those of the combined group was higher than those of the chemotherapy group, the difference was statistically significant (P＜0.05). The total effective rate of combined group was higher than that of chemotherapy group (P＜0.05). The expression levels of proto-oncogenes c-erbB2, c-myc and K-ras in the two groups after treatment were lower than those before treatment, and the expression levels in the combined group were lower than those in the chemotherapy group (P＜0.05). After treatment, the expression of tumor suppressor genes P53, P16 and PTEN in the two groups were higher than those before treatment, and the expression of tumor suppressor genes in the combined group was higher than that in the chemotherapy group (P＜0.05). The incidence of adverse reactions in combined group was lower than that in chemotherapy group (P＜0.05). Conclusions: IMRT combined with chemotherapy after endometrial cancer surgery can effectively improve the treatment effect, improve the quality of life of patients and the expression of proto-oncogene and anti-oncogene, with fewer adverse reactions, which is worthy of clinical application.

Key words: Radiotherapy, intensity-modulated, Antineoplastic combined chemotherapy protocols, Endometrial neoplasms, Proto-oncogenes, Genes, tumor suppressor

CLC Number:

ZHANG Ming-chuan, WANG Li. Effect of Intensity-Modulated Radiotherapy Combined with Chemotherapy on Oncogene in Patients with Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2019, 46(5): 591-594.

References

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