Abstract: Regulatory T cell is a kind of special T cell subpopulation with immunoregulatory function. Among them, CD4+CD25+Treg cell subpopulation is the most widely studied, and its important role is to regulate the immune tolerance function of the body. It can inhibit the activation and proliferation of CD8+ and CD4+ effector T cells by direct contact, and then prevent the occurrence of autoimmune diseases. In the field of tumor, more and more studies have found that the proliferation of cancer cells is closely related to the invasion and the imbalance of patients′ autoimmune regulation. Ovarian cancer is one of the most common gynecological malignancies. With the incidence ranking the third, the death rate of ovarian cancer accounts for the first place in gynecological malignant tumors. It has the characteristics of occult incidence, strong invasion, rapid metastasis, and lack of powerful treatment. The purpose of this article is to seek new methods for the early diagnosis and treatment of ovarian cancer at the immunological level, so as to improve the survival rate of patients through the overview of CD4+CD25+Treg and the review of the current progress of studies on CD4+CD25+Treg and ovarian cancer.

Key words: Ovarian neoplasms;, Carcinoma, T-lymphocytes, regulatory, Immune regulation, CD4-positive T-lymphocytes;, CD8-positive T-lymphocytes