The Advance of Impaired Decidualization in the Pathogenesis of Preeclampsia

doi:10.12280/gjfckx.20210283

Abstract

Abstract:

Preeclampsia is a pregnancy-related disorder which seriously affects maternal and fetal health. Its etiology and pathogenesis have not been clarified yet. How to predict, diagnose and treat preeclampsia has always been the focus of attention in the field of obstetrics and gynecology. Decidualization of the endometrium provides a critical nutrient and immune matrix for embryo implantation and development. However, impaired decidualization caused by biological dysfunction of decidual cells (proliferation, differentiation, apoptosis, angiogenesis and energy metabolism) can affect the invasion of trophoblast cells, resistance to inflammation, oxidative stress, and immune protection, and impair embryo implantation and pregnancy maintenance, and thus regulate the occurrence and development of preeclampsia. To fully understand the role of decidualization defeat caused by abnormal biological function of decidual cells in the pathogenesis of preeclampsia will provide more theoretical basis for the prediction, diagnosis and treatment of preeclampsia.

Key words: Pre-eclampsia, Cell proliferation, Apoptosis, Glycolysis, Cell differentiation, Impaired decidualization

YANG Jie-qiong, ZHANG Cong, DI Wen. The Advance of Impaired Decidualization in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 490-493.

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