The Role of Autophagy in Fetal Growth Development and Pregnancy Complications

doi:10.12280/gjfckx.20220816

Abstract

Abstract:

Autophagy is a highly conserved intracellular material removal mechanism, which has the function of maintaining cell homeostasis and promoting metabolic recycling and maintaining energy balance. Autophagy is as well a self-stabilizing process which facilitates cell survival. Studies have demonstrated that autophagy plays an important role in the differentiation, development, invasion of trophoblast and the process of maternal spiral artery recasting. Autophagy sustains pregnancy by removing damaged mitochondria and endoplasmic reticulum to maintain cellular homeostasis. Autophagy runs through the whole process of fetal growth and development. Associated factors such as Beclin-1, damage-regulated autophagy modulator, microtubule-associated protein light chain 3B and so on, are continuously expressed in the placenta during the whole gestation period and remain at a relatively high level in the third trimester. Studies have shown that the dysfunction of autophagy is tightly related to pregnancy complications such as preeclampsia, fetal growth restriction and premature delivery, in which mitochondrial autophagy plays an important role.

Key words: Autophagy, Embryonic development, Pregnancy complications, Pre-eclampsia, Fetal growth retardation, Abortion, spontaneous

WU Ya-mei, LI Meng, LI Jia-wen, YING Hao, HUANG Lu. The Role of Autophagy in Fetal Growth Development and Pregnancy Complications[J]. Journal of International Obstetrics and Gynecology, 2023, 50(2): 121-126.

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