Abstract: P53 gene is one of the most important human tumor suppressor genes relative to tumorigenesis，and its mutations are found in approximately 50% of cancers. Though P53 is expressed lower in cervical cancer tissues with the main wild-type. The codon 72 polymorphism in exon 4 of wtP53 is closely associated with occurrence of cervical carcinomas. In cervical cancer cells the half-life of wtP53 protein is shorter, and the function is inactivated. wtP53 regulate of cell cycle, promotion of tumor cells apoptosis, and inhibition of tumor cell growth. A variety of genes such as E6, E7, MDM2, STAT3 can inactivate wtP53 and induce the degradation of wtP53.

Key words: Wild type P53, Human papillomavirus, Cervical cancer, Apoptosis