Abstract: Gestational diabetes mellitus (GDM) as the prophase of type 2 diabetes (T2DM) and the onset of the key points is insulin resistance (IR). Current of GDM screening time is during 24-28 weeks of pregnancy. However, this time has been the middle and late pregnancy, before delivery to the GDM intervention time is short and the test is time-consuming, laborious and increase the potential of pregnant women with GDM glucose load, therefore, looking for early prediction of GDM factors, not only to improve the efficiency of GDM screening, but also to prevent and reduce the occurrence of GDM play an important role. There have been a large number of early screening GDM related research in the world, which focus on inflammatory factors, adipocytokines, liver enzymes and other aspects of metabolism. More and more research support of T2DM is in the status of chronic inflammation hypothesis, there is a higher inflammatory factor concentration increased. Liver and adipoes tissue as the main places of IR, involved in carbohydrate metabolism and maintain glucose homeostasis. In recent years, a study shows that there is a correlation between the liver metabolism, adipocytokines and the pathogenesis of GDM. In this paper, the research progress of the early prediction of GDM in recent years is reviewed.

Key words: Diabetes，gestational, Cytokines, Adipocytokines, Blood glucose, Hemoglobins, Forecasting