Abstract: Objective：To investigate the relationship and the application value of plasma D-dimer and leucine aminopeptidase (LAP) in the hypertensive disorders complicating pregnancy (HDCP). Methods：A number of 404 healthy  pregnant women and 101 healthy non-pregnant women were enrolled from the obstetrical examination department of Fujian Medical University Affiliated Nanping First Hospital from August 2015 to December 2016, and a total of 116 HDCP were enrolled from the Obstetrics and Gynecology Department of Nanping First Hospital from August 2015 to December 2016. LAP, alkaline phosphatase (ALP), plasma D-dimer, urine total protein and urine creatinine of all the subjects were detected, and value of urinary total protein/creatinine ratio (UTPCR) was calculated. Single factor analysis of variance, Pearson correlation analysis and Trend chart were performed to test the relationship between plasma D-dimer and LAP, UTPCR. Results：Compared with the healthy non-pregnant women and various stages of healthy pregnant women, systolic blood pressure, D-dimer, UTPCR of HDCP were significantly higher (P<0.05), and LAP of HDCP significantly lower than that of late healthy pregnancy period (P<0.05). Correlation analysis showed that D-dimer of late healthy pregnancy women was only related to urinary protein (r=0.19, P=0.011), D-dimer of HDCP was strongly correlated to gestational period (r=-0.505, P=0.000), LAP (r=-0.443, P=0.001), UTPCR (r=0.372, P=0.004). Trend graph showed that D-dimer level of HDCP was significantly higher than that of the corresponding period of healthy pregnant women, and LAP level of HDCP was obviously lower. Conclusions：Plasma D-dimer is preferably related to LAP in HDCP, and plasma D-dimer, LAP and UTPCR are the important basises for early detection, treatment and prevention for HDCP.

Key words: Hypertension, pregnancy-induced, D-dimer, Leucine aminopeptidase, Urinary total protein/creatinine ratio