Abstract:

In recent years, the research of endometrial microbiota has gradually gained attention. The composition of microbial communities in different proportions is closely related to the occurrence of reproductive system disease and pathological pregnancies. The composition of endometrial microbiota has not yet been fully elucidated. Many studies hold the view that lactobacilli dominate the endometrial microbiome, but this theory remains controversial due to differences in sample collection and analysis methods across studies. The 16S rRNA sequencing technology is currently the most commonly used method for studying the endometrial microbiota, although studies using different omics technologies have also been reported. Endometrial receptivity is crucial for successful embryo implantation, and the dominance of lactobacilli in the endometrium may be associated with improved reproductive outcomes. Chronic endometritis (CE) has been confirmed to be associated with infertility, recurrent miscarriage, and repeated implantation failure. Although the correlation between endometrial microbial imbalance and CE has not yet been established, some studies have found that a decrease in the proportion of lactobacilli in CE patients, suggesting a potential association between the endometrial microbiome and CE. This paper reviews the different research findings and methods on the composition of endometrial microbiome and summarizes the recent impacts and roles of endometrial microbiota on endometrial receptivity and CE.

Key words: Microbiota, Endometrium, Endometrial microbiota, Endometrial receptivity, Chronic endometritis