Journal of International Obstetrics and Gynecology ›› 2025, Vol. 52 ›› Issue (3): 257-261.doi: 10.12280/gjfckx.20250261
• Gynecological Disease & Related Research: Original Article • Previous Articles Next Articles
LIU Lin-lin(), HUANG Xiao-wu, XIA En-lan
Received:
2025-03-14
Published:
2025-06-15
Online:
2025-06-19
Contact:
LIU Lin-lin
E-mail:wslinlin26@hotmail.com
LIU Lin-lin, HUANG Xiao-wu, XIA En-lan. Reproductive Prognosis after Minimally Invasive Surgery for Herlyn-Werner-Wunderlich Syndrome[J]. Journal of International Obstetrics and Gynecology, 2025, 52(3): 257-261.
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序 号 | 年龄 (岁)* | 手术方式 | HWWS | 子宫体 类型 | 妊娠 方式 | 首次妊娠距手术间隔时间 | 术后妊娠情况 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
位置 | 分类 | 合并泌尿系统畸形 | 分娩 孕周 | 分娩 方式 | 特殊情况 | ||||||
1 | 25 | 2次宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 双子宫 | 自然 | 4个月 | 35+周 | CS | 斜隔侧妊娠,早产,斜隔对侧子宫腔(左侧)子宫蜕膜脱落大出血,妊娠期保胎2个月 |
2 | 26 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | IVF-ET | 5+年 | 足月 | CS | 斜隔侧妊娠,术后多次IVF成功,足月CS |
3 | 30 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 6个月 | 足月 | CS | 斜隔侧妊娠 |
4 | 31 | 宫腔镜手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 6个月 | 足月 | CS | 斜隔侧妊娠 |
5 | 31 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 12个月 | 足月 | CS | 斜隔侧妊娠 |
6 | 30 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 2年 | 足月 | CS | 斜隔侧妊娠 |
7 | 26 | 宫腔镜手术 | 右侧 | Ⅲ型 | 右肾缺如 | 双子宫 | 自然 | 22个月 | 36+6周 | CS | 斜隔对侧腔妊娠,胎儿宫内生长受限,早产,出生体质量2 290 g |
8 | 25 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双子宫 | 自然 | 10个月 | 足月/35+周/36+周 | CS | 斜隔侧妊娠3次(人工流产1次,早孕胎停育1次,足月CS 1次),斜隔对侧妊娠2次(早产CS 2次) |
9 | 28 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 6+个月 | 足月 | CS | 妊娠早期保胎治疗 |
10 | 32 | 宫腔镜手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 11个月 | 34+周 | CS | 早产 |
11 | 27 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 12个月 | 足月 | CS | 无特殊 |
12 | 27 | 宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 6年 | 足月 | CS | 无特殊 |
13 | 26 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 完全纵隔子宫 | 自然 | 6个月 | 足月 | CS | 无特殊 |
14 | 26 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 完全纵隔子宫 | 自然 | 6个月 | 足月 | CS | 之后再次自然妊娠,瘢痕妊娠,栓塞后清宫,未再生育 |
15 | 30 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 双肾正常 | 完全纵隔子宫 | IVF-ET | 3年 | 足月 | CS | 因输卵管因素IVF -ET 1次成功,妊娠早期保胎治疗 |
16 | 25 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全双角子宫 | 自然 | 12个月 | 35周 | CS | 斜隔对侧腔妊娠,孕35周早产,出生体质量2 600 g |
17 | 34 | 宫腹腔镜联合手术+妊娠前腹腔镜下宫颈环扎术 | 左侧 | Ⅱ型 | 双肾正常 | 完全纵隔子宫 | 自然 | 7年 | - | 流产 | 3次妊娠中期自然流产,其中孕18周2次,孕20周1次 |
18 | 33 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | IVF-ET | 10年 | - | 流产 | IVF-ET成功后,孕8周胎停育1次 |
19 | 31 | 宫腹腔镜联合手术 | 右侧 | Ⅲ型 | 右肾缺如 | 不全纵隔子宫 | 自然 | 5年 | - | 流产 | 孕12+周胎儿脐膨出行引产术 |
20a | 26 | 宫腹腔镜联合手术+腹腔镜双角子宫融合术 | 右侧 | Ⅱ型 | 右肾缺如 | 双角子宫 | 自然 | 5个月 | - | 流产 | 术前异位妊娠1次,术后孕3个月胎停育1次 |
21a | 39 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 双肾正常 | 双角子宫 | - | - | - | 未临床 妊娠 | 术前稽留流产2次,术后生化妊娠2次 |
22 | 33 | 宫腔镜手术+宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 完全双角子宫 | - | - | - | 未临床 妊娠 | 2次手术,多次IVF失败 |
23 | 33 | 宫腔镜手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双角子宫 | - | - | - | 未临床 妊娠 | 不孕1+年 |
24 | 24 | 宫腹腔镜联合手术 | 左侧 | Ⅰ型 | 左肾缺如 | 完全双角子宫 | - | - | - | 未临床 妊娠 | 不孕2+年 |
25 | 23 | 宫腔镜手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双子宫 | - | - | - | 未临床 妊娠 | 试孕2个月未成功 |
序 号 | 年龄 (岁)* | 手术方式 | HWWS | 子宫体 类型 | 妊娠 方式 | 首次妊娠距手术间隔时间 | 术后妊娠情况 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
位置 | 分类 | 合并泌尿系统畸形 | 分娩 孕周 | 分娩 方式 | 特殊情况 | ||||||
1 | 25 | 2次宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 双子宫 | 自然 | 4个月 | 35+周 | CS | 斜隔侧妊娠,早产,斜隔对侧子宫腔(左侧)子宫蜕膜脱落大出血,妊娠期保胎2个月 |
2 | 26 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | IVF-ET | 5+年 | 足月 | CS | 斜隔侧妊娠,术后多次IVF成功,足月CS |
3 | 30 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 6个月 | 足月 | CS | 斜隔侧妊娠 |
4 | 31 | 宫腔镜手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 6个月 | 足月 | CS | 斜隔侧妊娠 |
5 | 31 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 12个月 | 足月 | CS | 斜隔侧妊娠 |
6 | 30 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 双子宫 | 自然 | 2年 | 足月 | CS | 斜隔侧妊娠 |
7 | 26 | 宫腔镜手术 | 右侧 | Ⅲ型 | 右肾缺如 | 双子宫 | 自然 | 22个月 | 36+6周 | CS | 斜隔对侧腔妊娠,胎儿宫内生长受限,早产,出生体质量2 290 g |
8 | 25 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双子宫 | 自然 | 10个月 | 足月/35+周/36+周 | CS | 斜隔侧妊娠3次(人工流产1次,早孕胎停育1次,足月CS 1次),斜隔对侧妊娠2次(早产CS 2次) |
9 | 28 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 6+个月 | 足月 | CS | 妊娠早期保胎治疗 |
10 | 32 | 宫腔镜手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 11个月 | 34+周 | CS | 早产 |
11 | 27 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 12个月 | 足月 | CS | 无特殊 |
12 | 27 | 宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 完全纵隔子宫 | 自然 | 6年 | 足月 | CS | 无特殊 |
13 | 26 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 完全纵隔子宫 | 自然 | 6个月 | 足月 | CS | 无特殊 |
14 | 26 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 左肾缺如 | 完全纵隔子宫 | 自然 | 6个月 | 足月 | CS | 之后再次自然妊娠,瘢痕妊娠,栓塞后清宫,未再生育 |
15 | 30 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 双肾正常 | 完全纵隔子宫 | IVF-ET | 3年 | 足月 | CS | 因输卵管因素IVF -ET 1次成功,妊娠早期保胎治疗 |
16 | 25 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全双角子宫 | 自然 | 12个月 | 35周 | CS | 斜隔对侧腔妊娠,孕35周早产,出生体质量2 600 g |
17 | 34 | 宫腹腔镜联合手术+妊娠前腹腔镜下宫颈环扎术 | 左侧 | Ⅱ型 | 双肾正常 | 完全纵隔子宫 | 自然 | 7年 | - | 流产 | 3次妊娠中期自然流产,其中孕18周2次,孕20周1次 |
18 | 33 | 宫腹腔镜联合手术 | 右侧 | Ⅱ型 | 右肾缺如 | 完全纵隔子宫 | IVF-ET | 10年 | - | 流产 | IVF-ET成功后,孕8周胎停育1次 |
19 | 31 | 宫腹腔镜联合手术 | 右侧 | Ⅲ型 | 右肾缺如 | 不全纵隔子宫 | 自然 | 5年 | - | 流产 | 孕12+周胎儿脐膨出行引产术 |
20a | 26 | 宫腹腔镜联合手术+腹腔镜双角子宫融合术 | 右侧 | Ⅱ型 | 右肾缺如 | 双角子宫 | 自然 | 5个月 | - | 流产 | 术前异位妊娠1次,术后孕3个月胎停育1次 |
21a | 39 | 宫腹腔镜联合手术 | 左侧 | Ⅱ型 | 双肾正常 | 双角子宫 | - | - | - | 未临床 妊娠 | 术前稽留流产2次,术后生化妊娠2次 |
22 | 33 | 宫腔镜手术+宫腹腔镜联合手术 | 右侧 | Ⅰ型 | 右肾缺如 | 完全双角子宫 | - | - | - | 未临床 妊娠 | 2次手术,多次IVF失败 |
23 | 33 | 宫腔镜手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双角子宫 | - | - | - | 未临床 妊娠 | 不孕1+年 |
24 | 24 | 宫腹腔镜联合手术 | 左侧 | Ⅰ型 | 左肾缺如 | 完全双角子宫 | - | - | - | 未临床 妊娠 | 不孕2+年 |
25 | 23 | 宫腔镜手术 | 左侧 | Ⅱ型 | 左肾缺如 | 双子宫 | - | - | - | 未临床 妊娠 | 试孕2个月未成功 |
[1] | 朱兰, 郎景和, 宋磊, 等. 关于阴道斜隔综合征、MRKH综合征和阴道闭锁诊治的中国专家共识[J]. 中华妇产科杂志, 2018, 53(1):35-42. doi: 10.3760/cma.j.issn.0529-567x.2018.01.008. |
[2] | Burgis J. Obstructive Müllerian anomalies: case report, diagnosis, and management[J]. Am J Obstet Gynecol, 2001, 185(2):338-344. doi: 10.1067/mob.2001.116738. |
[3] | Tridenti G, Brunl Y, Ghirardini G. Double uterus with a blind hemivagina and ipsilateral renal agenesis: clinical variants in three adolescent women: case report and literature review[J]. J Pediatr Adolesc Gynecol 1995,8:201-207. doi: 10.1016/S0932-8610(19)80143-3. |
[4] | Zurawin RK, Dietrich JE, Heard MJ, et al. Didelphic uterus and obstructed hemivagina with renal agenesis: case report and review of the literature[J]. J Pediatr Adolesc Gynecol, 2004, 17(2):137-141. doi: 10.1016/j.jpag.2004.01.016. |
[5] |
Wang J, Zhu L, Lang J, et al. Clinical characteristics and treatment of Herlyn-Werner-Wunderlich syndrome[J]. Arch Gynecol Obstet, 2014, 290(5):947-950. doi: 10.1007/s00404-014-3286-5.
pmid: 24866888 |
[6] | 卞美璐, 黄荣丽, 吴葆桢, 等. 先天性阴道斜隔[J]. 中华妇产科杂志, 1985, 20(2):85-88. |
[7] |
Liu Y, Li Z, Dou Y, et al. Anatomical variations, treatment and outcomes of Herlyn-Werner-Wunderlich syndrome: a literature review of 1673 cases[J]. Arch Gynecol Obstet, 2023, 308(5):1409-1417. doi: 10.1007/s00404-022-06856-y.
pmid: 36823415 |
[8] |
Albulescu DM, Ceausescu AE, Sas LM, et al. The Herlyn-Werner-Wunderlich triad (OHVIRA syndrome) with good pregnancy outcome - two cases and literature review[J]. Rom J Morphol Embryol, 2018, 59(4):1253-1262.
pmid: 30845309 |
[9] | Kita M, Shiraga H, Fukuda H, et al. Successful pneumovaginoscopic surgery for recurrent abscess of OHVIRA syndrome, preventing further recurrence and subsequent pregnancy[J]. Asian J Endosc Surg, 2024, 17(1):e13270. doi: 10.1111/ases.13270. |
[10] | Zhu L, Chen N, Tong JL, et al. New classification of Herlyn-Werner-Wunderlich syndrome[J]. Chin Med J(Engl), 2015, 128(2):222-225. doi: 10.4103/0366-6999.149208. |
[11] |
Candiani M, Vercellini P, Ferrero-Caroggio C, et al. Conservative treatment of Herlyn-Werner-Wunderlich syndrome: Analysis and long-term follow-up of 51 cases[J]. Eur J Obstet Gynecol Reprod Biol, 2022, 275:84-90. doi: 10.1016/j.ejogrb.2022.06.013.
pmid: 35763966 |
[12] | Bunnell ME, Cipres DT, Laufer MR. Case Series of Reproductive Outcomes after Surgical Correction of Obstructed Hemivagina in OHVIRA[J]. AJP Rep, 2024, 14(1):e26-e30. doi: 10.1055/a-2208-0032. |
[13] |
Propst AM,Hill JA 3rd. Anatomic factors associated with recurrent pregnancy loss[J]. Semin Reprod Med, 2000, 18(4):341-350. doi: 10.1055/s-2000-13723.
pmid: 11355792 |
[14] |
Tong J, Zhu L, Lang J. Clinical characteristics of 70 patients with Herlyn-Werner-Wunderlich syndrome[J]. Int J Gynaecol Obstet, 2013, 121(2):173-175. doi: 10.1016/j.ijgo.2012.11.023.
pmid: 23465857 |
[15] |
Heinonen PK. Pregnancies in women with uterine malformation, treated obstruction of hemivagina and ipsilateral renal agenesis[J]. Arch Gynecol Obstet, 2013, 287(5):975-978. doi: 10.1007/s00404-012-2680-0.
pmid: 23247278 |
[16] | Fedele L, Motta F, Frontino G, et al. Double uterus with obstructed hemivagina and ipsilateral renal agenesis: pelvic anatomic variants in 87 cases[J]. Hum Reprod, 2013, 28(6):1580-1583. doi: 10.1093/humrep/det081. |
[17] |
Haddad B, Barranger E, Paniel BJ. Blind hemivagina: long-term follow-up and reproductive performance in 42 cases[J]. Hum Reprod, 1999, 14(8):1962-1964. doi: 10.1093/humrep/14.8.1962.
pmid: 10438409 |
[18] | 王彩霞, 胡晴丽. 妊娠晚期阴道斜隔综合征误诊1例[J]. 广东医学, 2014, 35(11):1800. doi:10.13820/j.cnki.gdyx.2014.11.067. |
[19] | 傅雪雯, 汪期明, 刘丹秋, 等. 妊娠合并阴道斜隔综合征一例[J]. 现代实用医学, 2020, 32(3):417-418. doi: 10.3969/j.issn.1671-0800.2020.03.068. |
[20] | Rana R, Pasrija S, Puri M. Herlyn-Werner-Wunderlich syndrome with pregnancy: a rare presentation[J]. Congenit Anom(Kyoto), 2008, 48(3):142-143. doi: 10.1111/j.1741-4520.2008.00195.x. |
[21] |
Baños Cándenas L, Abehsera Davó D, de la Peña Rodríguez de Medina M, et al. Diagnosis and gestational follow-up in a patient with Herlyn-Werner-Wünderlich syndrome, a case report[J]. Taiwan J Obstet Gynecol, 2019, 58(4):560-565. doi: 10.1016/j.tjog.2019.05.023.
pmid: 31307752 |
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