Abstract: Objective：To investigate the effect of ovarian stimulation with low-dose hCG combined with HMG on infertility patients with hypogonadotropic hypogonadism. Mehtods：Five infertility patients with hypogonadotropic hypogonadism were undergone ovarian stimulation with 50 IU hCG combined with HMG. Vaginal ultrasound-B，serum sexual hormone were used to monitor determine follicular development. Results：Four infertility patients with hypogonadotropic hypogonadism were undergone ovulation induction with six cycles，the mean number of ovulation was 2.6±1.5，ovulation rate was 100%，cumulating pregnancy rate was 100%. No moderate and severe OHSS occurred. No patients were undergone with surplus follicle aspiration or switched to IVF-ET. No patients were with high order multiple pregnancies. One patient with hypogonadotropic hypogonadism was undergone controlled ovarian hyperstimulation（COH） for one cycle，7 follicles were undergone aspiration，5 oocytes were harvested. After insemination，3 zygotes formed，and cleaved into 2 good-quality embryos. With embryo-transfer， one embryo was found in uterine cavity，one in tube. After surgery，the patient delivered one infant finally. Conclusions：Low-dose hCG combined with HMG could be safely and effectively used to ovarian stimulation on infertility patients with hypogonadotropic hypogonadism，and could improve the results of ovarian stimulation.

Key words: Hypogonadism, Chorionic gonadotropin, Infertility, female, Follicle stimulating hormone