Abstract: Recently research indicate that an imbalance of maternal circulating pro-and anti-angiogenic factors may play a role in the pathogenesis of preeclampsia. Thrombospondin（TSP） is a protein expressed in various cells such as platelet，
endothelial cells，matrix fiber cells，vascular smooth muscle cells，interstitial cells and immunocyte，which acts as a potent
antiangiogenic agent. TSP affects several cellular functions，including proliferation，motility，adhesion，apoptosis and infiltrate make the endometrial spiral arterioles vessel tone stricture and rejection，induce placenta blood flow reduce，then induce preeclampsia.

Key words: Thrombospondins, Pre-eclampsia, Vascular endothelial growth factors, Fibroblast growth factors