Abstract: In recent years, with the development of minimally invasive technique, laparoscopic surgery in gynecology field has been gradually dominant and tends to replace the traditional laparectomy surgery. Compared with the traditional surgery, laparoscopic surgery in 2D images, needing pneumoperitoneum to exposure the surgical field. With the increase in the number of cases of laparoscopic surgery and surgical expansion of the scope surgery, the complications of laparoscopic surgery has gradually been recognized. CO2 pneumoperitoneum can lead to peritoneal mesothelium cell swellon, connection terminated and basement membrane became exposed, inhibit the activity of abdominal macrophage, NK cells, T lymphocytes. This article will review the influence of CO2 pneumoperitoneum on peritoneum and internal-abdomen environment.

Key words: Carbon dioxide, Peritoneum, Macrophage, Killer cells, natural, T-lymphocytes