Abstract: The silent information regulator 2 (Sir2) and family proteins are highly conserved NAD+(nicotinamide adenine dinucleotide)-dependent deacetylases, and were originally discovered in yeast. SIRT1 is the highest homology with Sir2 in mammal, is considered to be long-lived protein limited by energy to give play to the role of anti-aging. SIRT1 regulates physiological processes through histones and non-histone proteins to extend life span, such as adjusting the energy metabolism, lipid oxidation and delay the onset of old age diseases such as cardiovascular development, and anti-aging. Studies have shown that estrogen plays a vital role in anti-aging. Conventional viewpoints suggested that estrogen combined with the estrogen receptor (ER) in directly or indirectly to activate the target genes in anti-aging. However, recent research shows that estrogen up-regulated SIRT1 by multiple pathways and delayed cell senescence. This paper discuss the anti-aging mechanism of estrogen by summarizing the expression pathways of estrogen up-regulating SIRT1.

Key words: Estrogens, Caloric restriction, Sirtuins, Telomerase, Aging