叶酸与不良生育的相关研究

doi:10.12280/gjfckx.20200467

摘要/Abstract

摘要：

不良生育主要包括早期复发性流产、胎儿发育异常等。不良生育给家庭及社会造成严重负担,减少出生缺陷是妇产科医生的一项重要工作。不良生育发病原因复杂,是遗传及环境因素综合作用的结果。叶酸与不良生育的关系始终是一个研究热点,其中叶酸缺乏或利用障碍是导致胎儿神经管畸形比较明确的一种因素。此外,叶酸缺乏还可能与早期复发性流产、男性不育及胎儿唇腭裂、先天性心脏病、唐氏综合征等其他出生缺陷有关。尽管目前相关研究较多,但其中的具体发病机制尚不清晰。近年来有许多研究从遗传基因及组蛋白修饰等表观遗传学方面阐述了叶酸缺乏与不良生育的相关性。结合近年来相关文献,从叶酸转运吸收、叶酸代谢及相关酶多态性、叶酸缺乏导致各种不良生育及其发病机制进行综述,为更进一步研究两者之间的关系奠定理论基础。

关键词: 叶酸, 代谢, 流产,自然, 不育,男（雄）性, 先天畸形

Abstract:

Adverse pregnancy mainly includes early recurrent abortion, abnormal fetal development and so on. Adverse pregnancy imposes a heavy burden on families and society. Reducing birth defects is an important task for obstetricians and gynecologists. The cause of adverse fertility is complex, which is the result of the combination of genetic and environmental factors. Folic acid is a hot research topic that leads to adverse pregnancy. Folic acid deficiency or utilization disorder is a well-established cause of fetal neural tube defects. Folic acid deficiency may also be associated with recurrent abortion, male sterility, and other birth defects such as cleft lip and palate, congenital heart disease and Down syndrome. Although there are many relevant studies, the specific pathogenesis is still unclear. In recent years, many studies have elucidated the correlation between folic acid deficiency and adverse fertility from the aspects of gene and histone modified epigenetics. Based on the relevant literature in recent years, the paper reviews folic acid transport absorption, folic acid metabolism and related enzyme polymorphism, folic acid deficiency leading to various adverse fertility and its pathogenesis, to lay a theoretical foundation for further research on the relationship between them.

Key words: Folic acid, Metabolism, Abortion,spontaneous, Infertility,male, Congenital abnormalities

胡浩梅, 杨华. 叶酸与不良生育的相关研究[J]. 国际妇产科学杂志, 2021, 48(1): 89-94.

HU Hao-mei, YANG Hua. Research between Folic Acid and Adverse Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 89-94.

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