PD-1/PD-L1抑制剂治疗复发或转移性宫颈癌的研究进展

doi:10.12280/gjfckx.20211154

摘要/Abstract

摘要：

宫颈癌是全球女性癌症相关死亡的第四大原因。对于复发或转移性宫颈癌,5年生存率仅有17%,这促使临床医生探索新的治疗方案。程序性死亡-1（programmed death-1,PD-1）/程序性死亡配体-1（programmed death ligand-1,PD-L1）抑制剂作为一种免疫治疗手段,在复发或转移性宫颈癌中已表现出一定的优势,但临床数据质量有待进一步提高。研究表明抗血管生成类药物、放化疗的应用可协同PD-1/PD-L1抑制剂的抗癌活性。回顾性梳理总结PD-1/PD-L1抑制剂用于宫颈癌的理论基础及应用现状、联合其他治疗模式的临床试验,以期改善晚期宫颈癌患者的生存预后,讨论并发的免疫相关不良反应和疗效评估指标,以便更好地管理不良反应、指导临床用药。

关键词: 程序性细胞死亡受体1, 宫颈肿瘤, 肿瘤复发,局部, 肿瘤转移, 肿瘤治疗方案, 程序性死亡配体-1

Abstract:

Cervical cancer is the fourth leading cause of cancer-related deaths in women worldwide. The 5-year survival rate is only 17% for recurrent or metastatic cervical cancer, which impels clinicians to explore new treatment strategies. As an immunotherapy, PD-1/PD-L1 inhibitors have shown certain advantages in recurrent or metastatic cervical cancer, but the quality of clinical data needs to be further improved. Observations have shown the significant synergy of anti-angiogenesis agents, radiotherapy and chemotherapy with PD-1/PD-L1 inhibitors. For the purpose of the improved prognosis of patients with advanced cervical cancer, the team provides an overview of the theoretical basis and application status of PD-1/PD-L1 inhibitors in cervical cancer, as well as several clinical trials in combination with other treatment modes. The team also discusses the subsequent immune-related adverse events and the biomarkers for the evaluation of immunotherapy, so as to better manage adverse reactions and guide clinical medication.

Key words: Programmed cell death 1 receptor, Uterine cervical neoplasms, Neoplasm recurrence, local, Neoplasm metastasis, Antineoplastic protocols, Programmed death ligand-1

韩品, 温静, 刘雨晨, 孙怡, 王元培, 任芳. PD-1/PD-L1抑制剂治疗复发或转移性宫颈癌的研究进展[J]. 国际妇产科学杂志, 2022, 49(4): 393-397.

HAN Pin, WEN Jing, LIU Yu-chen, SUN Yi, WANG Yuan-pei, REN Fang. Research Progress of PD-1/PD-L1 Inhibitors in Patients with Recurrent or Metastatic Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 393-397.

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