国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 412-415.

• 综述 • 上一篇    下一篇

肿瘤坏死因子α在多囊卵巢综合征中的作用

丁 涛， 马红霞   

  1. 510182 广州医学院（丁涛）；广州医学院第一附属医院中医科（马红霞）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 马红霞

The Action of Tumor Necrosis Factor-α in Polycystic Ovarian Syndrome

DING Tao，MA Hong-xia   

  1. Guangzhou 510182，China（DING Tao）；Department of Traditional Chinese Medicine of the First Affiliated Hospital of Guangzhou Medical College，Guangzhou 510120，China（MA Hong-xi
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15
  • Contact: MA Hong-xia

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摘要： 多囊卵巢综合征（PCOS）是育龄期妇女常见的生殖内分泌疾病，其病因及发病机制复杂，尽管提出了很多假说，但其确切的发病机制仍不十分清楚。近年研究显示，肿瘤坏死因子α（TNF-α）与该病关系密切，其参与胰岛素抵抗、高雄激素血症、肥胖、排卵障碍以及黄体功能不全等多个方面。就TNF-α在PCOS代谢异常中的作用及对卵巢功能的影响做文献综述。

关键词: 多囊卵巢综合征, 肿瘤坏死因子α, 胰岛素抗药性, 肥胖症, 糖尿病

Abstract: Polycystic ovary syndrome （PCOS） is a common disease among reproductive-aged women. The etiology and pathogenesis of PCOS is complex，although a lot of hypothesis have been proposed，the exact mechanism is still unclear. Recent of studies have suggested that the tumor necrosis factor-α involved in insulin resistance， hyperandrogenism， obesity，ovulation failure and corpus luteum insufficiency of PCOS. This review briefly introduced the tumor necrosis factor-α′s action in the metabolic disorder and the effect of ovarian function in PCOS.

Key words: Polycystic ovary syndrome, Tumor necrosis factor-alpha, Insulin resistance, Obesity, Diabetes mellitus