国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 432-435.

• 综述 • 上一篇    下一篇

相关细胞因子在预测宫内感染中的意义

胡金艳,王晨虹   

  1. 518028 广东省深圳市，南方医科大学附属深圳妇幼保健院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15

Clinical Significance of Cytokines Detection in Prediction of Intrauterine Infection

HU Jin-yan，WANG Chen-hong   

  1. Department of Obstetrics，Shenzhen Maternity ＆ Child Health Care Hospital，the Affiliated Hospital of Southern Medical University，Shenzhen 518028，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15

PDF (PC)

4776

被引次数

7

摘要： 宫内感染对妊娠的影响及对母儿造成的危害日益受到关注，其可导致早产及围生儿死亡、新生儿呼吸窘迫综合征等不良妊娠结局；但目前以临床诊断为主，使许多亚临床感染的孕产妇得不到及时诊治，而宫内感染一旦出现临床症状时病情往往已经危重，近年，预测宫内感染的相关研究成为热点。研究表明，白细胞介素10、粒细胞集落刺激因子、白细胞介素6、基质金属蛋白酶9、高迁移率族蛋白1、人类β防御素等细胞因子对宫内感染有一定的预测价值，联合蛋白组学方法可能实现宫内感染的早期诊断、早期治疗。综述宫内感染预测的相关细胞因子的研究近况。

关键词: 妊娠并发症, 感染性, 粒细胞集落刺激因子, C反应蛋白质, 白细胞介素6, 基质金属蛋白酶9, 高迁移率族蛋白质类, β防御素, 蛋白质组学

Abstract: Angiogenic factors and anti-angiogenic factors have been studied in many areas. Now，they have become a hot spot in the Pathological obstetric，many research are on the preeclampsia in maternal plasma，but the role of stillbirth in them is still ralely repored. This paper mainly discusses the clinical etiology of stillbirth，the significance of PIGF、 sVEGFR-1、sEng change and the reasons for stillbirth of amniotic fluid and maternal serum of endothelial growth factor receptor-1、placental growth factor and soluble endoglin sEng concentration. We make a detailed study of the relationship between changes of anti-angiogenic and Anti-angiogenic factor and the occurrence of stillbirth，open up new ideas for the etiology and pathogenesis of stillbirth.

Key words: Fetal death, Angiogenesis inducing agents, Vascular endothelial growth factor receptor-1, Pathology