Research Progress on the Relationship between Endocan and Pre-Eclampsia

doi:10.12280/gjfckx.20200798

Abstract

Abstract:

Pre-eclampsia is a unique disease during pregnancy, and its pathogenesis is the research focus of many scholars. Vascular endothelial cell dysfunction is one of the main pathophysiological changes generally recognized. As a new type of biomarker for endothelial dysfunction, endothelial cell-specific molecule (endocan) can protect endothelium from the migration and proliferation of inflammatory cells. Vascular system diseases, tumors, sepsis, etc. have been extensively studied and become effective targets for diagnosis and treatment of diseases. Recent studies have found that endocan is differentially expressed in the serum and placenta of patients with pre-eclampsia, suggesting that endocan may be involved in the pathogenesis of pre-eclampsia. Therefore, in-depth study of the relationship between endocan and pre-eclampsia will help reveal the pathogenesis of pre-eclampsia and provide a basis for early prevention and treatment of the disease. This article reviews the research progress of the relationship between endocan and pre-eclampsia.

Key words: Pre-eclampsia, Endocan, Vasular endothelial growth factors, Endothelial dysfuction

SUI Xin-shuang, SUN Jing-xia, YUAN Jing, CAO Shan, DAI Chen-guang. Research Progress on the Relationship between Endocan and Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 169-173.

References 32

[1]	Phipps EA, Thadhani R, Benzing T, et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies[J]. Nat Rev Nephrol, 2019,15(5):275-289. doi: 10.1038/s41581-019-0119-6. doi: 10.1038/s41581-019-0119-6 pmid: 30792480
[2]	Brosens I, Brosens JJ, Muter J, et al. Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries[J]. Am J Obstet Gynecol, 2019,221(3):219-226. doi: 10.1016/j.ajog.2019.01.239. doi: 10.1016/j.ajog.2019.01.239 pmid: 30738027
[3]	Tomimatsu T, Mimura K, Matsuzaki S, et al. Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors[J]. Int J Mol Sci, 2019,20(17):4246. doi: 10.3390/ijms20174246.
[4]	Bessa J, Albino-Teixeira A, Reina-Couto M, et al. Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases[J]. Clin Chim Acta, 2020,509:310-335. doi: 10.1016/j.cca.2020.07.041. doi: 10.1016/j.cca.2020.07.041 pmid: 32710940
[5]	赵海燕, 王晓非. Endocan在呼吸系统和心血管系统疾病中作用的研究进展[J]. 医学综述, 2018,24(17):3345-3349. doi: 10.3969/j.issn.1006-2084.2018.17.004.
[6]	Lassalle P, Molet S, Janin A, et al. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines[J]. J Biol Chem, 1996,271(34):20458-20464. doi: 10.1074/jbc.271.34.20458.
[7]	Kali A, Shetty KS. Endocan: a novel circulating proteoglycan[J]. Indian J Pharmacol, 2014,46(6):579-583. doi: 10.4103/0253-7613.144891. doi: 10.4103/0253-7613.144891 pmid: 25538326
[8]	Leite AR, Borges-Canha M, Cardoso R, et al. Novel Biomarkers for Evaluation of Endothelial Dysfunction[J]. Angiology, 2020,71(5):397-410. doi: 10.1177/0003319720903586. pmid: 32077315
[9]	Mahmoud EA, Moneim WA, Shaker OG, et al. Expression of endocan and vascular endothelial growth factor in recurrent minor aphthous ulcers[J]. J Clin Exp Dent, 2019,11(6):e534-534e541. doi: 10.4317/jced.55695. doi: 10.4317/jced.55695 pmid: 31346373
[10]	Canpolat U, Kocyigit D, Yildirim A. Role of Endothelial Dysfunction and Endocan in Atherosclerosis: Point of Origin or End Point?[J]. Angiology, 2020,71(5):477. doi: 10.1177/0003319716654627. doi: 10.1177/0003319716654627 pmid: 27307222
[11]	Sun H, Zhang H, Li K, et al. ESM-1 promotes adhesion between monocytes and endothelial cells under intermittent hypoxia[J]. J Cell Physiol, 2019,234(2):1512-1521. doi: 10.1002/jcp.27016. doi: 10.1002/jcp.27016 pmid: 30144067
[12]	Gaudet A, Portier L, Prin M, et al. Endocan regulates acute lung inflammation through control of leukocyte diapedesis[J]. J Appl Physiol (1985), 2019,127(3):668-678. doi: 10.1152/japplphysiol.00337.2019.
[13]	Ngene NC, Moodley J. Role of angiogenic factors in the pathogenesis and management of pre-eclampsia[J]. Int J Gynaecol Obstet, 2018,141(1):5-13. doi: 10.1002/ijgo.12424. doi: 10.1002/ijgo.12424 pmid: 29222938
[14]	Su T, Zhong Y, Demetriades AM, et al. Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice[J]. Invest Ophthalmol Vis Sci, 2018,59(2):930-939. doi: 10.1167/iovs.17-22945. pmid: 29450540
[15]	Rocha SF, Schiller M, Jing D, et al. Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability[J]. Circ Res, 2014,115(6):581-590. doi: 10.1161/CIRCRESAHA.115.304718. doi: 10.1161/CIRCRESAHA.115.304718 pmid: 25057127
[16]	杨舒奇, 黄明莉, 黄凌佳, 等. 血管内皮生长因子家族在妇产科若干疾病中的研究进展[J]. 中国生育健康杂志, 2020,31(2):184-186,190. doi: 10.3969/j.issn.1671-878X.2020.02.021.
[17]	孙嘉敏, 陈先侠. miRNA-29b及血管内皮生长因子在子痫前期病程中的作用机制[J]. 解放军医学院学报, 2019,40(11):1074-1078. doi: 10.3969/j.issn.2095-5227.2019.11.016.
[18]	王丽婷. HIF-1α、VEGF、sFlt-1在子痫前期患者胎盘组织中的表达及临床意义[J]. 中国计划生育学杂志, 2020,28(3):366-369. doi: 10.3969/j.issn.1004-8189.2020.03.015.
[19]	Lee B, Shin H, Oh JE, et al. An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, CTNNB1[J]. Autophagy, 2020 Jun 17: 1-18. doi: 10.1080/15548627.2020.1778292. doi: 10.1080/15548627.2021.1899681 pmid: 33779490
[20]	Niktalab R, Piravar Z, Behzadi R. Different Polymorphisms of Vascular Endothelial Growth Factor Gene in Patients with Pre-Eclampsia among The Iranian Women Population[J]. Int J Fertil Steril, 2020,14(1):41-45. doi: 10.22074/ijfs.2020.5787. doi: 10.22074/ijfs.2020.5787 pmid: 32112634
[21]	Shah S, Gupta A. Hypertensive Disorders of Pregnancy[J]. Cardiol Clin, 2019,37(3):345-354. doi: 10.1016/j.ccl.2019.04.008. doi: 10.1016/j.ccl.2019.04.008 pmid: 31279428
[22]	Cakmak M, Yilmaz H, Bağlar E, et al. Serum levels of endocan correlate with the presence and severity of pre-eclampsia[J]. Clin Exp Hypertens, 2016,38(2):137-142. doi: 10.3109/10641963.2015.1060993. doi: 10.3109/10641963.2015.1060993 pmid: 26418319
[23]	Adekola H, Romero R, Chaemsaithong P, et al. Endocan, a putative endothelial cell marker, is elevated in preeclampsia, decreased in acute pyelonephritis, and unchanged in other obstetrical syndromes[J]. J Matern Fetal Neonatal Med, 2015,28(14):1621-1632. doi: 10.3109/14767058.2014.964676. pmid: 25211383
[24]	Hentschke MR, da Cunha Filho EV, Vieira MC, et al. Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia[J]. Rev Bras Ginecol Obstet, 2018,40(10):593-598. doi: 10.1055/s-0038-1670713. doi: 10.1055/s-0038-1670713 pmid: 30352456
[25]	Agrawal S, Shinar S, Cerdeira AS, et al. Predictive Performance of PlGF (Placental Growth Factor) for Screening Preeclampsia in Asymptomatic Women: A Systematic Review and Meta-Analysis[J]. Hypertension, 2019,74(5):1124-1135. doi: 10.1161/HYPERTENSIONAHA.119.13360. doi: 10.1161/HYPERTENSIONAHA.119.13360 pmid: 31522621
[26]	Schuitemaker J, Cremers T, Van Pampus MG, et al. Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies[J]. Pregnancy Hypertens, 2018,12:58-64. doi: 10.1016/j.preghy.2018.02.012. pmid: 29674200
[27]	Chew BS, Ghazali R, Othman H, et al. Endocan expression in placenta of women with hypertension[J]. J Obstet Gynaecol Res, 2019,45(2):345-351. doi: 10.1111/jog.13836. pmid: 30306675
[28]	Lan X, Liu Z. Circulating endocan and preeclampsia: a meta-analysis[J]. Biosci Rep, 2020,40(1):BSR20193219. doi: 10.1042/BSR20193219. doi: 10.1042/BSR20192825 pmid: 31904821
[29]	李小琳. 血液Endocan水平与子痫前期相关性的Meta分析[D]. 洛阳:河南科技大学, 2019.
[30]	Chang X, Bian Y, Wu Y, et al. Endocan of the maternal placenta tissue is increased in pre-eclampsia[J]. Int J Clin Exp Pathol, 2015,8(11):14733-14740. pmid: 26823798
[31]	Kucukbas GN, Sanhal CY, Uygur D. Plasma Endocan Levels in Early and Late-Onset Preeclampsia[J]. Fetal Pediatr Pathol, 2019 Nov 26: 1-8. doi: 10.1080/15513815.2019.1693674. doi: 10.1080/15513815.2020.1843573 pmid: 33150803
[32]	Szpera- Goździewicz A, Kosicka K, Goździewicz T, et al. Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy[J]. J Matern Fetal Neonatal Med, 2020,33(14):2313-2319. doi: 10.1080/14767058.2018.1548597. doi: 10.1080/14767058.2018.1548597 pmid: 30501553