Research Progress on Molecular Mechanism and Molecular Typing of Endometrial Carcinoma

doi:10.12280/gjfckx.20210256

Abstract

Abstract:

The incidence of endometrial carcinoma has been on the rise in recent years and the age of onset is getting younger. The treatment effect of advanced endometrial cancer is not ideal. The traditional classification method has serious deficiencies in the diagnosis and treatment of patients, and cannot provide sufficient basis for accurate treatment of patients. With the rapid development of molecular biology, more and more multi-omics studies and signal pathway associations in the onset of endometrial cancer have been discovered, and there is an urgent clinical need to include it in the routine diagnosis and treatment of patients. This article summarizes the latest progress in molecular biology and signaling pathways of type I and type II endometrial carcinoma. The diagnosis and prognosis of type I endometrial carcinoma are related to PTEN, PI3KCA, PI3KR1, ARID1A, KRAS, POLE, CTNNB1, TP53 mutation, MMR deletion, ER and PR expression are related. The prognosis of type II endometrial cancer is related to HER2 overexpression, TP53 mutation, and ARID1A mutation. PI3K/Akt, P53, MAPK and Wnt/β-catenin signaling pathways are closely related to the pathogenesis of endometrial carcinoma. ProMisE and Parra-Herran molecular classification, an alternative to TCGA classification, are currently used clinically to assess the prognosis and treatment options of endometrial carcinoma, but there are still some cases that do not match the prognosis, further refinement of the typing is needed.

Key words: Endometrial neoplasms, Molecular biology, Signal transduction, Genes, Mutation

YANG Lin, CAI Yu-han, LI Hua. Research Progress on Molecular Mechanism and Molecular Typing of Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 10-14.

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