Abstract: It is difficulty for early detection of epithelial ovarian cancer, which lead to a high fatality rate.
Effective early screening or treatment should be based on a detailed understanding of disease pathogenesis. The traditional view of ovarian cancer asserts that all tumor subtypes share a common origin in ovarian surface epithelium, but it has limitation. Fallopian tube as a site of origin may have been answered by a series of studies investigating the prevalence of occult fallopian tube cancer in women with germline BRCA gene mutations. We study ovarian surface epithelium and cortical inclusion cysts, two-pathway model and fallopian tube as a site of origin in order to help the early diagnosis and therapy of epithelial ovarian cancer.

Key words: Ovarian neoplasms, Genes, p53, Fallopian tubes, Neoplasms, glandular and epithelial