Abstract: Epigenetics is the study branch of genetic variation of apparent genetics. In recent years，with further research，epigenetics displays their invaluable role and broad prospects in human growth and development period and the idiopathic pregnant diseases and their prevention and control. In mammalian germ cells and preimplantation developmental stages，its occurs genome methylation patterns through the large-scale demethylation and then re-methylation reprogramming，resulting in a developmental potential cells. Environmental factors during pregnancy，including exposure to toxic hazardous substances，endocrine disruptors，as well as food，medicines can change the epigenetic model，leading to various diseases in pregnant women and their offspring.

Key words: Genomic imprinting, DNA methylation, Fetal growth retardation, Pre-eclampsia, Epigenetics