Abstract: Stathmin was detected expression in human endometrial epithelia and stromal cells and impacted in the progression of cell cycles as a microtuble unstable protein. It was reported that the transformation from endometrium to decidua is an important characteristics of embryo implantation. Stathmin may play a critical role in endometrial decidualization， differentiation and proliferation，apoptosis of decidual，invasion and adhesion of the decidual related cells. As an important feature of normal implantation and pregnancy， decidualization and sub-surface trophoblast constitute a maternal-fetal interface， thus affecting the normal early pregnancy， and may be related to early spontaneous abortion. This article will summarize the studies about stathmin with the decidualization.

Key words: Microtubule proteins, Stathmin, Endometrium, Decidua