Abstract: sFlt-1 and Flt-1 belong to the vascular endothelial growth factor receptor（VEGFR），sFlt-1 competition binding with VEGF，completely abolished the biological activity of VEGF， inhabited angiogenesis and affected the vascular wall barrier integrity and permeability. Placental growth factor（PLGF） is a member of the VEGF family，PLGF binds with Flt-1 receptor，and promotes angiogenesis and trophoblast proliferation. These biological functions can be blocked by sFlt-1 receptor，sFlt-1 plays an important role in regulate PLGF. sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease. Levels of PLGF are lower in preeclampsia serum compare to normal. sFlt-1 plays a major role in the pathogenesis of preeclampsia， it is unclear how hypoxia regulates placental sFlt-1 expression，maybe the PI3K-Akt pathway plays an important role in regulating the expression of sFlt-1. sFlt-1 and PLGF might be used as markers for predicting preeclampisa.

Key words: Vascular endothelial growth factor receptor-1, Placenta, Pre-eclampsia, Microvessel density, Signal transduction