Journal of International Obstetrics and Gynecology ›› 2012, Vol. 39 ›› Issue (3): 271-275.

• 综述 • Previous Articles     Next Articles

sFlt-1,PLGF and Their Role in Pathogensis and Prediction of Preeclampsia

HE Shu-qiong, YAN Jian-ying   

  1. Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Child Health Hospital,Fu jian Medical University Teaching Hospital,Fuzhou 350001,China(now studying at Fujian Medical University)
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: YAN Jian-ying

Abstract: sFlt-1 and Flt-1 belong to the vascular endothelial growth factor receptor(VEGFR),sFlt-1 competition binding with VEGF,completely abolished the biological activity of VEGF, inhabited angiogenesis and affected the vascular wall barrier integrity and permeability. Placental growth factor(PLGF) is a member of the VEGF family,PLGF binds with Flt-1 receptor,and promotes angiogenesis and trophoblast proliferation. These biological functions can be blocked by sFlt-1 receptor,sFlt-1 plays an important role in regulate PLGF. sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease. Levels of PLGF are lower in preeclampsia serum compare to normal. sFlt-1 plays a major role in the pathogenesis of preeclampsia, it is unclear how hypoxia regulates placental sFlt-1 expression,maybe the PI3K-Akt pathway plays an important role in regulating the expression of sFlt-1. sFlt-1 and PLGF might be used as markers for predicting preeclampisa.

Key words: Vascular endothelial growth factor receptor-1, Placenta, Pre-eclampsia, Microvessel density, Signal transduction