Abstract: The liver X receptor（LXR）is a member of the nuclear receptor superfamily,originally described as
orphan receptor.It is now known LXR exists in two homologous isoforms: LXRα（NR1H3）and LXRβ（NR1H2）isoforms.Present studies have turn out that LXR has a relationship with sterol regulatory element-binding protein-1（SREBP-1）,
oxidatively modified low density lipoprotein（oxLDL）, nitric oxide（NO）, matrix metalloproteinases（MMPs）, Endoglin
（CD105）and human chorionic gonadotropin（hCG）which also participate in the pathogenesis of preeclampsia, demonstrating that LXR is associated with lipid metabolism, vascular endothelial injury, trophoblast cell proliferation and invasiveness as well. Therefore the abnormal expressivity of LXR may plays an important role in the development of preeclampsia.

Key words: Receptors, cytoplasmic and nuclear, Pre-eclampsia, Lipid metabolism, Endothelium, vascular, Liver X receptor