Abstract: Long non-coding RNAs (lncRNAs) are a group of RNA molecules which are longer than 200 nucleotides and they cannot encode proteins. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of gene expression network at transcriptional, post-transcriptional and epigenetic levels, which may affect growth, proliferation, differentiation, metabolism, apoptosis and other important physiological processes of cells. In cervical cancer, lncRNA may act as the tumor promoter or tumor suppressor. It is becoming evident that lncRNAs may be an important class of pervasive genes involved in the regulation of multiple cellular biological processes, including apoptosis, tumor invasion and metastasis. lncRNA is hopefully to become the new type of molecular marker and therapeutic target in the diagnosis and treatment of cervical cancer. Combined with domestic and foreign latest reports, there are mainly six lncRNAs may have the role of carcinogenesis: HOX transcription antisense RNA (HOTAIR), lung adenocarcinoma metastasis related transcripts 1 (MALAT1), H19, EBIC, Linc-p21 and brain cell mass(BC200), and mainly two lncRNAs may have the function of cervical cancer suppressor: maternal imprinted genes 3 (MEG3) and XLOC_010588, changing their expression levels of cells may has an obvious effect on the mutiple biological behaviors such as cell proliferation, invasion. Moreover, they are closely associated with clinical pathologic factors of cervical cancer and influence the prognosis of disease.

Key words: Long non-coding RNAs, Uterine cervical neoplasms, Genes, tumor suppressor