Abstract: Preeclampsia (PE) is a common complication during pregnancy and a major cause of poor pregnancy outcomes, which can even lead to maternal and child death in severe cases. PE involves multiple links, causing multiple organ, system involvement. Preeclampsia is a complex, multisystem disorder relate to abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress and inflammation. Although there are many studies on PE, the pathogenesis of PE is not clear, and its occurrence may be related to the age of pregnant women, chronic hypertension, diabetes, pre-pregnancy obesity and multiple pregnancy. Studies found that the related factors of thrombus formation and related inflammatory factors are related to the pathogenesis of PE, which can promote the pathogenesis of PE, but the specific mechanism is unknown. Clarifying the correlation of thrombosis and inflammation in the pathogenesis of PE can provide relevant strategies for the early prevention and treatment of PE. Therefore, this paper reviews the role of thrombus formation and inflammation in the pathogenesis and development of PE.

Key words: Pre-eclampsia, Thrombosis, Inflammation, Angiogenesis inducing agents factors, Complement system proteins, Thromboplastin