Abstract: Recurrent spontaneous abortion (RSA) is clinically defined that they had been at least three or more consecutive pregnancy losses, which is one of the common complications of pregnancy. Multiple factors can lead to RSA, such as chromosomal or endocrine abnormalities, blood type, immune, physiological anatomical abnormalities and genital tract infections. The occurrence and development of RSA is closely related to immune factors, especially in immune cells and the cytokines secreted by them. The balance between helper T cells (Th) and the cytokines secreted by them is of great significance, so control the steady state becomes a new breakthrough for the treatment of RSA by immunology. Janus kinase/signal transducers and activators of transcription (JAK/STAT) signal transduction pathway is the most widely studied and recognized pathways in the signaling pathways that regulate immune molecules. While RSA occurs, the expression of the key molecules of JAK/STAT signal transduction pathway changes significantly, and JAK/STAT signal transduction pathway can mediate the signal transduction of a variety of cytokines.

Key words:  Abortion, spontaneous, Abortion, habitual, T-lymphocytes, helper-inducer, Immunologic factors, JAK/STAT pathway