Research Progress on the Mechanism of Obesity Influencing Endometrial Decidualization

doi:10.12280/gjfckx.20210003

Abstract

Abstract:

Endometrial decidualization is necessary for embryo implantation, placental formation, and maintenance of pregnancy. Impaired decidualization is associated with multiple adverse pregnancy outcomes. At present, the obesity population has increased significantly, which has different degrees of damage to health. The mRNA expression of prolactin and insulin-like growth factor binding protein 1 in the decidual stromal cells of obese women decreased significantly. Obesity affected progesterone-related protein, insulin receptor substrate 2, signal transduction and activator 3, Wnt protein and decidual immune cells involved in decidualization, which was closely related to the impaired decidualization. To study the correlation between obesity and endometrial decidualization damage is helpful to further understand the pathogenesis of endometrial decidualization damage and to prevent decidualization damage and improve the adverse pregnancy outcome. Further research on this aspect may provide a new idea for the diagnosis and treatment of obese patients with recurrent pregnancy loss.

Key words: Obesity, Endometrium, Decidualization, Gene expression, Immunity,cellular, Decidua

WANG Meng-yao, GONG Zheng, XIA Tian, DOU Zhen, ZHAO Zhi-mei. Research Progress on the Mechanism of Obesity Influencing Endometrial Decidualization[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 642-645.

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