Abstract: The implantation of the blastocyst into the maternal uterus is a crucial step in mammalian reproduction. The successful establishment of pregnancy requires an interaction between the blastocyst and receptive uterus，then trophoblasts invade the endometrium accurately. And the decidualization of endometrium is considered a major factor in this process. Similar to tumor metastasis，embryonic implantation also include identification，adhesion，invasion and transfer process. Differently，the invasion of trophoblast has a “self-limited” cell behavior，and it is exactly controled by a complex network of various cells and molecules. Transmembrane 4 superfamily members play an important role in a series of biological actions，such as cell adhesion，invasion and transfer，not only in the tumor metastasis，but also in the embryonic implantation.

Key words: Compomers, Glycoproteins, Cell membrane, Trophoblasts, Invasive, Embryo implantation