Abstract: Pre-eclampsia is a leading cause of death of the pregnant women and the perinatal fetus，but the cause has not been clear. Present study suggests that endothelial cell injury，angiogenesis inhibition and vascular inflammation are very important in the pathogenesis. The release of some factors of placenta and blood vessel-derived circulating factors，including VEGF， sFlt-1， AT1-AA ，TNF-a， IL-1， IL-6， PTX3 can cause vascular endothelial extensive damage and systemic inflammatory response by various means. Vasomotor factor imbalance， the decreasing expression of vascular relaxing factor such as NO、prostacyclin、adrenomedullin and the increasing expression of vascular contraction factor such as angiotensin Ⅱ、endothelin can also lead to vascular dysfunction. Some of these markers also serve as a predictor of preeclampsia incidence.

Key words: Pre-eclampsia, Vascular endothelial growth factors, C-Reactive protein, Tumor necrosis factor- alpha, Interleukins