Top Read Articles

Published in last 1 year |

In last 2 years |

In last 3 years |

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Low-Grade Endometrial Stromal Sarcoma JI An-xuan, ZHANG Qun, WANG Qing, ZHAO Shu-hua Journal of International Obstetrics and Gynecology    2022, 49 (6): 611-615.   DOI: 10.12280/gjfckx.20220277 Abstract （2587）   HTML （36）    PDF （705KB）（2958）       Knowledge map    Low-grade endometrial stromal sarcoma (LG-ESS) is a rare type of malignant tumor of mesenchymal origin, which is also known as the most common subtype of endometrial stromal sarcoma. As a genetically heterogeneous disease, LG-ESS has many characteristic chromosomal translocations. Abnormal fusion proteins expressed by fusion genes are an important driving factor for the development of LG-ESS and also provide potential therapeutic targets for LG-ESS. LG-ESS is a low-grade malignant tumor characterized by slow growth and late recurrence, with pelvic radiation and long-term use of tamoxifen or estrogen as important risk factors. Due to the atypial of clinical manifestations, there is still a lack of effective preoperative diagnosis. Morphology and combined application of immunohistochemical antibodies can improve the detection rate, but their value is limited. Therefore, its diagnosis and treatment remains a great challenge for clinicians. This article reviews the molecular mechanisms, clinical manifestations, pathological diagnosis, treatment and prognosis of LG-ESS. Reference | Related Articles | Metrics

Select

The Predictive Value of Naples Prognostic Score in FIGO Stage Ⅰ-Ⅱ Cervical Cancer Patients with Postoperative Recurrence and Metastasis LIU Zhi-chao, LIU Guo-yan, DOU Xian-feng, HE Qian, ZHAO Hai-ling Journal of International Obstetrics and Gynecology    2023, 50 (2): 223-227,233.   DOI: 10.12280/gjfckx.20220908 Abstract （2406）   HTML （44）    PDF （871KB）（2334）       Knowledge map    Objective: To investigate the prognostic value of Naples prognostic score (NPS) in predicting postoperative recurrence and metastasis of cervical cancer in patients with stage Ⅰ-Ⅱcervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO). Methods: The clinical data of 186 patients with FIGOⅠ-Ⅱ cervical cancer were collected retrospectively. The patients were divided into low-risk group (0), medium-risk group (1-2) and high-risk group (3-4) according to NPS. Patients were divided into non-recurrence or metastasis group (n=147) and recurrence or metastasis group (n=39) according to whether they had relapsed or not, and the differences in clinical characteristics between the two groups were compared. COX proportional hazards regression was used to analyze the factors influencing patients′ recurrence or metastasis. Kaplan-Meier method was used to compare the difference of disease-free survival (DFS) among patients with different NPS patients. Results: There were statistically significant differences in albumin, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), degree of differentiation and proportion of parametrial infiltration in low-risk, medium-risk and high-risk NPS groups (all P<0.05). COX regression analysis showed that NPS was an independent prognostic factor for recurrence or metastasis in patients with cervical cancer (HRhigh-risk vs. low-risk=14.304, 95%CI: 3.214-63.656, P<0.001). Subgroup analysis showed that DFS in NPS high-risk group was significantly lower than that in medium-risk group and low-risk group (Log-rank χ2=23.267, P<0.001). Patients with FIGO stage Ⅰ and Ⅱ had significantly lower DFS in the NPS high-risk group than in the medium-risk and low-risk groups (Log-rank χ2=15.760 and 8.294, respectively, P<0.05). Conclusions: NPS is an independent influencing factor of postoperative progress of patients with FIGOⅠ-Ⅱ cervical cancer, and patients with higher NPS have relatively shorter DFS. Table and Figures | Reference | Related Articles | Metrics

Select

Clinical Application of Mussel Adhesive Proteins Dressing in Wound Repair and Vaginal Microecological Recovery after Loop Electrosurgical Excision Procedure WEI Ying-ting, YANG Bin-lie, HUANG Li-xia, GU Li-ying, HONG Zu-bei, WANG Yu-hua, QIU Li-hua Journal of International Obstetrics and Gynecology    2022, 49 (5): 507-510.   DOI: 10.12280/gjfckx.20220506 Abstract （2212）   HTML （55）    PDF （826KB）（3616）       Knowledge map    Objective: To evaluate the clinical application value of mussel adhesive proteins (MAP) dressing in wound repair and vaginal microecological recovery after loop electrosurgical excision procedure (LEEP). Methods: Patients who underwent LEEP for pathological diagnosis of cervical squamous intraepithelial diseases from November 2020 to April 2021 were randomly divided into 30 MAP group and 30 placebo control group without MAP. Wound healing was compared between the two groups at the 3rd week after surgery and vaginal microecological changes were compared between the two groups at the 5th week after surgery. Results: At the 3rd week after LEEP, the proportion of wound healing in the MAP group was significantly higher than that in the control group (53.33% vs. 13.33%, P=0.001). At the 5th week after LEEP, the vaginal microecology of the MAP group was significantly improved compared with that of the control group (66.67% vs. 3.33%, P=0.000). Conclusions: MAP dressing can effectively shorten the wound healing time after LEEP and improve vaginal microecology. Table and Figures | Reference | Related Articles | Metrics

Select

Research Progress of Ferroptosis in Endometriosis PENG Pei-xuan, WANG Li Journal of International Obstetrics and Gynecology    2022, 49 (5): 481-485.   DOI: 10.12280/gjfckx.20220451 Abstract （2057）   HTML （215）    PDF （713KB）（3444）       Knowledge map    Endometriosis as a common gynecological benign disease, however, has malignant behaviors such as invasion, infiltration, and distant metastasis. Ferroptosis is a newly discovered form of programmed cell death mainly characterized by the excessive intracellular free Fe2+ that mediates the Fenton reaction to produce hydroxyl radicals, inhibition of the intracellular antioxidant enzyme glutathione peroxidase 4, and peroxidation of cell membrane lipids leading to cell death. Endometriosis lesions exhibit ferroptosis resistance, a feature that impairs ectopic endometrial clearance and promotes their proliferation and migration. And part of the cells in turn promotes angiogenesis through ferroptosis. Sperm and oocyte damage as well as embryotoxicity from ferroptosis contribute further to endometriosis related infertility. Reference | Related Articles | Metrics

Select

Endometriosis of Vaginal Stump 15 Years after Hysterectomy: A Case Report CHEN Xi, HU Yu-ping, HU Le, YANG Yong-xiu Journal of International Obstetrics and Gynecology    2022, 49 (5): 516-518.   DOI: 10.12280/gjfckx.20220340 Abstract （1981）   HTML （45）    PDF （2264KB）（3403）       Knowledge map    Endometriosis (EMs) is a common chronic inflammatory disease in women that refers to the presence of glands and stroma of the endometrium outside the uterine cavity, most commonly in the ovaries, pelvic peritoneal surfaces, or other pelvic tissues. We report a 48-year-old woman who developed vaginal stump endometriosis 15 years after hysterectomy for hysteromyoma. The patient was admitted to the hospital due to irregular vaginal bleeding accompanied by abdominal pain for 3 years and aggravation for 2 months. Enhanced CT of the whole abdomen found irregular soft tissue beside the left iliac vessels. After multidisciplinary consultation, the patient was diagnosed with vaginal stump disease and underwent laparoscopic exploration. Resection of the left vaginal stump mass was performed according to the intraoperative findings, and the excised tissue was confirmed to be EMs by paraffin section pathological examination. Combined with this case, we discussed and reviewed relevant literature to provide diagnosis and treatment ideas for clinical cases of vaginal bleeding after hysterectomy, so as to improve clinicians’ understanding of postoperative vaginal stump EMs. Table and Figures | Reference | Related Articles | Metrics

Select

Efficacy Evaluation of Neoadjuvant Chemotherapy for Cervical Cancer FENG Dan, SHEN Fu-jin Journal of International Obstetrics and Gynecology    2022, 49 (5): 529-534.   DOI: 10.12280/gjfckx.20220114 Abstract （1955）   HTML （34）    PDF （751KB）（3494）       Knowledge map    Cervical cancer is the most common malignant tumor in gynecology, which seriously threatens women′s life and health. It is a global public health problem that needs to be solved urgently. At present, the treatment of cervical cancer is mainly surgery and radiotherapy, supplemented by chemotherapy. Neoadjuvant chemotherapy (NACT) is a commonly used adjuvant therapy for patients with cervical cancer, which has the advantages of reducing the size of the primary tumor and tumor metastasis. However, due to individual variability and tumor heterogeneity, not all patients respond to chemotherapy. At the same time, NACT also has certain toxic reactions, such as hair loss, neutropenia and organ damage, and even lead to the death of patients. At present, serum squamous cell carcinoma antigen (SCC-Ag) and imaging examination are most commonly used to evaluate the efficacy of NACT, but they have some limitations. The evaluation methods of NACT for cervical cancer are reviewed from the aspects of imaging, pathology, molecular markers, toxicity and survival, to provide a basis for the clinical evaluation of NACT, and to help the selection and application of individualized treatment plans. Reference | Related Articles | Metrics

Select

Diagnosis and Treatment of High-Grade Squamous Intraepithelial Lesion in High-Risk HPV-Infected Postmenopausal Women Amineguli ·Maimaitimin, Ayidana ·Jumabieke, HAN Li-li Journal of International Obstetrics and Gynecology    2022, 49 (5): 535-539.   DOI: 10.12280/gjfckx.20220172 Abstract （1953）   HTML （28）    PDF （707KB）（3523）       Knowledge map    High-grade squamous intraepithelial lesion (HSIL) is associated with the persistent infection of high-risk human papilloma virus, are considered cervical precancerous lesions with the potential for cancer. Difficulty of diagnosis and treatment of HSIL are increased due to age-dependent changes to the cervix in postmenopausal women. Though cervical biopsy is the gold standard for diagnosing cervical lesions, it is also missed, but endocervical curettage can improve the accuracy of HSIL in menopausal women, especially when colposcopy is not satisfactory but suspicious cervical lesions. Although positive margins are considered a key factor in residual/recurrence of lesions after cervical resection, a negative margin does not mean that the lesion has been completely removed. Moreover, because of cervical atrophy, cervical shortening, disappearance of the vaginal vault and other reasons, the difficulty of cervical resection surgery and the risk of damage to adjacent organs such as bladder and rectum are increased. At the same time, the hormone level of menopausal women is reduced, the predilection site of cervical cancer transformation zone of cervical moved to the cervical canal, and colposcopy cannot find the suspicious part in time, resulting in missed diagnosis of cervical cancer. Therefore, it is of great clinical significance to explore the optimal scheme for diagnosis and treatment of cervical lesions in postmenopausal women. By analyzing the current status and problems faced by cervical HSIL in postmenopausal, it provides individualized theoretical guidance for the diagnosis and treatment of cervical lesions in them. Reference | Related Articles | Metrics

Select

Research Progress of Ovarian Sclerosing Stromal Tumor WANG Min, LI Jia-hui, CUI Jun-ze, MA Shuai Journal of International Obstetrics and Gynecology    2022, 49 (6): 635-639.   DOI: 10.12280/gjfckx.20220187 Abstract （1940）   HTML （17）    PDF （675KB）（2813）       Knowledge map    Sclerosing stromal tumor of the ovary is a rare clinical benign ovarian tumor with low incidence and unclear etiology. It is more common in young women, mostly with unilateral mass, often visit a doctor due to irregular menstrual bleeding or abdominal mass found in physical examination. Imaging examination showed changes such as "lake island sign", "fast in and slow out" and "centrality enhancement". Histopathology showed unilateral rounded cystic solid mass with "false lobule" as the characteristic lesion. Immunohistochemistry showed positive expression of inhibin, vimentin and actin. The diagnosis is mainly made by histopathology, and imaging examination has important reference value. Preoperative diagnosis is difficult and easily confused with ovarian fibroma, follicular membranous cell tumor, ovarian Kookenberg tumor, granulosa cell tumor, etc. Surgical treatment is the main means of treatment, mostly the affected side tumor resection or adnexectomy. Postoperative prognosis is good and ovarian function can be restored to normal. For the tumor with more nuclear mitosis and necrosis, it is necessary to be alert to the risk of recurrence, and long-term follow-up is recommended. Reference | Related Articles | Metrics

Select

The Role of S100 Protein in Endometriosis DUAN Yu-han, LI Nan, CHEN Lei, ZHANG Kun Journal of International Obstetrics and Gynecology    2022, 49 (5): 486-491.   DOI: 10.12280/gjfckx.20220524 Abstract （1914）   HTML （125）    PDF （755KB）（3577）       Knowledge map    The S100 protein family is a family of 25 members of calcium-binding proteins that bind to Ca2+ and perform biological functions inside and outside the cell, regulating various cellular processes such as proliferation, differentiation, inflammation, migration and invasion, apoptosis, Ca2+ homeostasis and energy metabolism. They are closely associated with the development of many cancers, inflammatory diseases and immune disorders. Endometriosis (EMs) has a complex pathogenesis and is a chronic inflammatory disease that can cause pelvic pain and infertility. There are no accurate and easily accessible early non-invasive diagnostic methods and clear therapeutic targets. Studies have shown that S100B, S100A7 and S100A8 can participate in the inflammatory response by activating the nuclear factor-κB (NF-κB) signaling pathway; S10013 can participate in neovascularization and promotes disease progression by synergizing with other pro-angiogenic factors; S100A4, S100A6 and S100P may induce cell migration and invasion through Wnt/β-catenin signaling pathway and/or p38 MAPK signaling pathway. The research progress on the role of S100 protein family in the pathogenesis and diagnosis of EMs is reviewed to provide ideas for further applications of S100 proteins in EMs, and to provide references for the search of potential early diagnostic markers and therapeutic targets. Reference | Related Articles | Metrics

Select

Laparoscopy Trocar Port Site Leiomyoma after Laparoscopic Myomectomy: A Case Report XU Qian, LI Na, LIU Xin, WANG Jin-juan Journal of International Obstetrics and Gynecology    2022, 49 (5): 549-551.   DOI: 10.12280/gjfckx.20211131 Abstract （1878）   HTML （22）    PDF （2917KB）（3355）       Knowledge map    Laparoscopy Trocar port site leiomyoma after laparoscopic myomectomy is very rare. Its pathogenesis may be related to iatrogenic implantation after pelvic surgery. This article reports a case of abdominal wall leiomyoma treated in the gynecology minimally invasive center of Beijing Obstetrics and Gynecology Hospital of Capital Medical University. The patient underwent laparoscopic myomectomy in our hospital at 2010. Six years ago, the patient felt a mass at the previous surgical scar on the left lower abdomen at 2015 and the mass that had been progressively increasing over a 3-year period since 2018. Laparotomy was performed on admission at 2021. During the operation, a 4.0 cm×4.0 cm leiomyoma nodule was found in the fat layer of the abdominal wall of the previous left laparoscopy Trocar port site. The abdominal wall leiomyoma was confirmed by histopathology and immunohistochemistry. The formation of leiomyoma in the abdominal wall of laparoscopy Trocar port site was considered to be iatrogenic parasitism caused by previous laparoscopic myomectomy. The prevention of iatrogenic parasitic leiomyoma is very important, but it cannot completely avoid the formation of iatrogenic parasitic leiomyoma, which needs further research. Table and Figures | Reference | Related Articles | Metrics

Select

Research Progress of Radical Trachelectomy for Early Stage Cervical Cancer CHEN Yue, LI Na, HU Yuan-jing Journal of International Obstetrics and Gynecology    2022, 49 (5): 524-528.   DOI: 10.12280/gjfckx.20220098 Abstract （1850）   HTML （33）    PDF （692KB）（3440）       Knowledge map    Cervical cancer is one of the most common gynecological malignant tumors. With the trend of younger age of cervical cancer, more and more patients have the requirement of sparing fertility. Radical trachelectomy has become the standard surgical method for preserving reproductive function in patients with International Federation of Gynecology and Obstetrics （FIGO） stage ⅠA2 and ⅠB1 cervical cancer,and has also been applied in patients with cervical cancer with tumor diameter >2 cm after neoadjuvant chemo therapy and patients with pregnancy complicated with cervical cancer. Radical trachelectomy has a large operation scope, great difficulty, long operation time and high incidence of postoperative complications. Surgical approach, intraoperative technique and the way of lymph node evaluation may have different effects on tumor prognosis and pregnancy outcome. Therefore, seeking a balance between tumor prognosis and reproductive function after radical trachelectomy, reducing unnecessary tissue resection and injury while ensuring tumor resection scope, shortening operation time and reducing the probability of complications can benefit more cervical cancer patients undergoing radical trachelectomy. Reference | Related Articles | Metrics

Select

Research Progress of Ovarian Brenner Tumor WAN Tao, YU Ping-yuan, XING Yi-juan, WANG Li, YANG Yong-xiu Journal of International Obstetrics and Gynecology    2023, 50 (1): 20-24.   DOI: 10.12280/gjfckx.20220427 Abstract （1795）   HTML （28）    PDF （774KB）（2378）       Knowledge map    Ovarian Brenner tumor is a rare pathological type of ovarian tumor, which can be divided into benign, borderline/atypical proliferalive and malignant. Its etiology and pathogenesis are still unclear, the clinical manifestations and imaging examinations are not specific, and it is easy to misdiagnose before surgery, and the diagnosis mainly depends on postoperative pathological examination. Recent studies have found that malignant Brenner tumor (MBT) gradually progresses from benign Brenner tumor of the ovaries, and the process of occurrence is related to the genetic variants of fibroblast growth factor receptor 3 (FGFR3) gene, CCND1 gene, and murine double microbody gene 2 (MDM2), cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and phosphoinositide 3-kinase catalytic alpha polypeptide (PIK3CA) gene. The treatment of ovarian Brenner tumor is mainly surgery, in which ovarian MBT can be supplemented with platinum-paclitaxel chemotherapy after surgery, and it is expected to be targeted therapy for its carcinogenic sites. Staging is an important prognostic factor, and early diagnosis and treatment is the key to improve prognosis. Reference | Related Articles | Metrics

Select

Application Progress of Tissue Clearing Three-Dimensional Imaging Technology in Ovarian Tissue CHEN Ying, HUANG Jin-zhi, WU Ke-feng, LI Qian Journal of International Obstetrics and Gynecology    2022, 49 (5): 492-496.   DOI: 10.12280/gjfckx.20220292 Abstract （1772）   HTML （109）    PDF （719KB）（3673）       Knowledge map    The ovaries are important organs of the mammalian reproductive system, and the understanding of the ovaries is mostly at the two-dimensional level. The rapid development of tissue clearing three-dimensional imaging technology provides an advanced platform for three-dimensional D visualization of the ovaries, which not only can be used to comprehensively image the normal and pathological ovarian tissues through tissue clearing and optical imaging microscopy techniques and explore ovarian tissue and its relationship with the vasculature and nervous system from the cellular or subcellular unit level, but also reveal the spatial relationship and structural characteristics of ovarian tissue. This technique can also analyze the three-dimensional structure and growth pattern of ovarian tumors, and study the density, integrity and morphological heterogeneity of the vasculature and nervous system, providing direction for the treatment and prognosis of ovarian tumors. In this article, we review the application progress of tissue clearing three-dimensional imaging technology in mammalian ovarian tissue, with a view to gaining a deeper understanding of ovarian tissue. Table and Figures | Reference | Related Articles | Metrics

Select

Clinical Analysis of 13 Cases of Primary Cervical Malignant Melanoma LI Nan, WANG Li-ying Journal of International Obstetrics and Gynecology    2022, 49 (5): 545-548.   DOI: 10.12280/gjfckx.20220018 Abstract （1769）   HTML （33）    PDF （672KB）（3337）       Knowledge map    Objective: To investigate the clinical characteristics, treatment and prognosis of primary cervical malignant melanoma. Methods: The clinical data and follow-up data of 13 patients with primary cervical malignant melanoma diagnosed by pathology in Affiliated Cancer Hospital of Zhengzhou University were collected from January 2013 to December 2019. Analysis the clinical characteristics, treatment and prognosis. Results: The 13 patients were 30-64 years old, with an average age of (51.1±10.8) years old. According to FIGO 2018 staging system, there were 4 stage Ⅰ patients, 3 stage Ⅱ patients, 1 stage Ⅲ patient, and 5 stage Ⅳ patients. Six patients with stage ⅠA-ⅡA were treated with surgery, of which 2 patients received observation only, 3 patients received chemotherapy after surgery, and one patient received chemotherapy+immunotherapy. Two patients with stage ⅡB to Ⅲ and two patients with stage Ⅳ received radiotherapy + chemotherapy. The remaining 3 patients with stage Ⅳ received a combination of chemotherapy, local radiotherapy, immunotherapy or targeted therapy. The median follow-up time was 12 months (7-84 months), 9 patients died, distant metastasis occurred in 3 cases, and the median overall survival was 38 months. Conclusions: Primary cervical malignant melanoma is a relatively rare but highly malignant tumor with poor prognosis and susceptibility to distant metastasis. Surgical resection is the main treatment modality for early-stage patients, and a combination of immunotherapy and targeted therapy may be a new option for metastatic and unresectable patients. Table and Figures | Reference | Related Articles | Metrics

Select

A Case of Abdominal Wall Endometriosis Involving Pubic Bone and Literature Review QIU Yu-qi, CHEN Yong Journal of International Obstetrics and Gynecology    2022, 49 (5): 511-515.   DOI: 10.12280/gjfckx.20220363 Abstract （1718）   HTML （38）    PDF （14239KB）（3398）       Knowledge map    A case of abdominal wall endometriosis involving pubic bone was successfully treated by surgical. The patient was diagnosed by abdominal wall ultrasound, pelvic magnetic resonance imaging and finally confirmed by fine needle biopsy. After admission, a multidisciplinary team including gynecologists, general surgeons, hernia surgeons, orthopedic surgeons and urologists was established to discuss and recommend surgical removal of abdominal wall endometriosis mass. The operation was completed by the multidisciplinary treatment team. Endometriosis was found in abdominal wall muscle, peritoneum and pubic symphysis. The endometriosis mass in the abdominal wall and pubic bone was completely removed. Because there were many abdominal muscles and fascia excised, the abdominal wall defect could not be sutured routinely. The abdominal wall defect was repaired with patches. The patient recovered well without complications and was followed up well. The successful treatment of this case showed that adequate preoperative examination and the cooperation of multidisciplinary treatment team were the key to the treatment of patients with complex abdominal wall endometriosis. For endometriosis involving pubic bone, tension-free hernia repair technique and postoperative compression bandage can be used as an alternative treatment for abdominal wall defect. Table and Figures | Reference | Related Articles | Metrics

Select

Effects of Fetal Growth Restriction on Fetal Brain Neurodevelopment YANG Jun-juan, ZHANG Yan Journal of International Obstetrics and Gynecology    2022, 49 (5): 570-573.   DOI: 10.12280/gjfckx.20211018 Abstract （1682）   HTML （21）    PDF （709KB）（3439）       Knowledge map    Fetal growth restriction (FGR) can cause short-term and long-term developmental abnormalities in fetuses and neonates and severe neurological diseases in adulthood. Therefore, the impact of FGR on fetal and neonatal brain neurodevelopment has become a research hotspot in recent years. Human and experimental animal studies have shown that the onset time of FGR, the severity of FGR, and the gestational age at delivery are closely related to fetal brain neurodevelopment. Middle cerebral artery Doppler ultrasonography and cerebroplacental ratio can evaluate fetal cerebral hemodynamics in FGR, and phase contrast magnetic resonance imaging can monitor fetal cerebral blood flow and brain structure. Early-onset and late-onset FGR have different effects on the brain neurodevelopment of the offspring. FGR can also lead to abnormal fetal brain structure and function, and increase the incidence of intraventricular hemorrhage. In this article, we reviewed the research progress of the effects of FGR on fetal brain neurodevelopment, in order to strengthen the clinical management of FGR fetuses and improve its short-term and long-term outcomes. Reference | Related Articles | Metrics

Select

The Experience of Transumbilical Laparoendoscople Single-Site Surgical Treatment by A Case of Accidental Detection of Low-Grade Endometrial Stromal Sarcoma YANG Xu, ZHENG Ying, CHEN Si-jing Journal of International Obstetrics and Gynecology    2023, 50 (1): 50-53.   DOI: 10.12280/gjfckx.20220723 Abstract （1682）   HTML （28）    PDF （5846KB）（2422）       Knowledge map    This article reports a case of low-grade endometrial stromal sarcoma (LG-ESS), which was accidentally found after 2 times of transumbilical laparoendoscople single-site surgery (TU-LESS), retrospectively. The patient was diagnosed with uterine fibroid before the first operation. The uterine fibroid was removed by TU-LESS bag cold knife rotary cutting. The pathological diagnosis was LG-ESS after the operation. After 30 days, a small amount of peritoneal planting was seen in the TU-LESS comprehensive staging operation again. Progesterone treatment was given after the operation. The tumor markers were normal after 20 months of follow-up. The umbilical incision and vaginal stump healed well. TU-LESS has the characteristics of light pain, beautiful wound, and rapid postoperative recovery. The most important thing is that the myoma specimens can be safely and effectively removed to avoid the widespread of sarcoma in the whole abdomen caused by the use of electric rotary cutter. However, during the operation, it is still necessary to be vigilant for peritoneal implantation caused by tumor splash during myomectomy, and each operation should strictly follow the principle of tumor-free. Table and Figures | Reference | Related Articles | Metrics

Select

Recurrence and Metastasis after Treatment of Extraskeletal Ewing Sarcoma Combined with Pregnancy and Successfully Delivery: A Case Report MA Xue-ying, YE Ling, WANG Xiao-hui Journal of International Obstetrics and Gynecology    2022, 49 (6): 687-690.   DOI: 10.12280/gjfckx.20220237 Abstract （1678）   HTML （11）    PDF （3754KB）（2734）       Knowledge map    Extraskeletal Ewing sarcoma in pregnancy is very rare in clinic, with a high rate of recurrence and metastasis, and there is no unified and effective treatment plan at present. This paper reports a case of pregnancy complicated with extraperitoneal Ewing sarcoma. Due to lumbosacral pain, a healthy full-term live female infant was successfully cesarean section in the First Hospital of Lanzhou University, who had previously received retroperitoneal tumor resection combined with left nephrectomy, supplemented with postoperative chemotherapy, combined with relevant medical history and examination to consider the recurrence and metastasis of extraperitoneal Ewing sarcoma. Because extraosseous Ewing sarcoma in pregnancy is very rare, the treatment is more difficult and the prognosis is poor. It is suggested that the suspected pregnant women should be followed up on the basis of regular prenatal examination in clinical work to find the focus in time. Once diagnosed, treatment strategies should be developed under the multi-disciplinary joint management mode to help patients overcome the challenges posed by pregnancy associated cancer and minimize adverse outcomes. Table and Figures | Reference | Related Articles | Metrics

Select

Research Progress in Diagnosis and Treatment of Uterine Intravenous Leiomyomatosis XU Qian, WANG Xin Journal of International Obstetrics and Gynecology    2022, 49 (6): 616-620.   DOI: 10.12280/gjfckx.20211159 Abstract （1677）   HTML （35）    PDF （676KB）（2722）       Knowledge map    Uterine intravenous leiomyomatosis (IVL) is a rare disease. The tumor typically grows along vascular vessels and can extend to the inferior vena cava, even to the heart. The pathogenesis remains still controversial at present. Most scholars are inclined to consider that the leiomyoma directly invades into myometrial veins and spreads along the vascular lumen. Uterine IVL usually occurs in 40 to 50 years old women with a reproductive history. The clinical manifestations in the early stages are not typical. If the lesion involves the inferior vena cava or right heart, it can cause ascites, hepatosplenomegaly, dyspnea, heart failure, and even sudden death in severe cases. Surgery is currently the preferred treatment method, but there is no consensus on the specific surgical plan. The recurrence rate of the disease is high, and long-term and close follow-up is required after the operation. The pathogenesis, high risk fators, clinical and imaging manifestations, diagnosis and differential diagnosis, treatment and prognosis of uterine IVL are reviewed, in order to provide references for the diagnosis and treatment of the disease in the future. Reference | Related Articles | Metrics

Select

New Progress in Treatment of Neuroendocrine Carcinoma of the Cervix PAN Zhong-mian, FENG Li-yuan, LI Li Journal of International Obstetrics and Gynecology    2023, 50 (1): 35-38.   DOI: 10.12280/gjfckx.20220396 Abstract （1664）   HTML （29）    PDF （734KB）（2593）       Knowledge map    Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly malignant gynecological carcinoma. Clinically, the origin and pathogenesis of NECC are not clear. There is no standard treatment protocol for NECC. Most of the treatments are based on the experience of cervical squamous cell carcinoma, adenocarcinoma and small cell lung cancer. Recent genomic studies in large sample cohorts have shown that different genomic characteristics between NECC and extracervical neuroendocrine carcinoma, raising questions about the biological and therapeutic correlation between NECC and extracervical neuroendocrine carcinoma. Due to the rarity of NECC, it is difficult to obtain sufficient numbers of patients for efficacy trials, making it difficult to develop a standard treatment regimen for NECC. Genetic testing provides a strategy for individualized treatment of NECC with targeted drugs. Multiple studies have shown that NECC has potential modifiable therapeutic targets, and the combination of immunotherapy and radiation therapy can prolong long-term survival in patients with advanced recurrent NECC. This article reviews the molecular characteristics, targeted drugs and immunotherapy of NECC. Reference | Related Articles | Metrics