Research Status of Correlation between Telomere Length and the Etiology of Spontaneous Abortion

doi:10.12280/gjfckx.20210034

Abstract

Abstract:

The study on the etiology of spontaneous abortion has always been a hot topic in the field of obstetrics and gynecology. The influence of various factors on pregnancy has been confirmed in numerous clinical studies, such as embryo, mother, father and environment, but there are still many cases of spontaneous abortion causes can not be explained. Telomeres are "cap" structures at the ends of linear DNA molecules in eukaryotic chromosomes, which are involved in maintaining chromosome stability and DNA replication integrity. Telomere plays an important role in the process of human reproduction, telomere length is closely related to the gamete and embryo development, positively correlated with the potential of embryonic stem cell proliferation. Most studies confirmed that spontaneous abortion is characterized by telomere shortening, especially in aneuploid embryos, and telomere length is in correlation with the mother, father and environmental factors. In this paper, the research on the correlation between telomere length and the etiology of spontaneous abortion is reviewed, to provide theoretical basis and direction guidance for the prevention and treatment of spontaneous abortion as well as further research.

Key words: Telomere, Telomere shortening, Telomere homeostasis, Abortion,spontaneous, Risk factors

BAI Le-le, ZHAO Xiao-xi. Research Status of Correlation between Telomere Length and the Etiology of Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 512-516.

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