Comparative Analysis of Serum Lipid Components between Pre-Eclampsia Patients and Normal Pregnant Women

doi:10.12280/gjfckx.20210780

Abstract

Abstract:

Objective：To compare and analyze the serum lipid components of pre-eclampsia (PE) patients and normal pregnant women. Methods：A total of 16 patients with pre-eclampsia admitted to the obstetrics department of the First Affiliated Hospital of Xi′an Medical University from January 1, 2019 to July 1, 2019 were included as PE group. Sixteen cases of normal pregnant women were selected as the normal control group (NC group), and serum of the two groups were collected. Five kind of lipid as glycerolipids, spingolipids, glycerides, sterols and fatty acids in serum of each group were analyzed by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results：There were no significant differences in the age and BMI of between the two groups (P>0.05). The gestational age of PE group was significantly decreased than that of NC group (P<0.05). A total of 25 lipid components were analyzed in serum of the two groups, and the results showed that compared with the NC group, the expression of glycerolipids, sphingolipids, glycerides and sterols in PE group had no statistical significance (P>0.05). The serum fatty acid content in PE group was significantly higher than that in NC group, and the difference was statistically significant (P<0.05). Further analysis of 13 different types of fatty acids showed that the serum levels of FFA22:4, FFA20:5, FFA20:4, FFA20:3, FFA18:2, FFA18:1, FFA16:1, FFA16:0 and FFA14:0 in pregnant women in PE group were significantly higher than those in NC group. The difference was statistically significant (P<0.05). Conclusions：Different types of fatty acids are differentially expressed in serum of PE patients. The above different types of FFA may be the early-warning molecules for disease diagnosis and play a certain role in disease prediction and mechanism exploration.

Key words: Pre-eclampsia, Fatty acids, Fatty acids,nonesterified, Glycerides, Sphingolipids

YANG Yang, MA Yuan, LUAN Li-xia, LI Mao. Comparative Analysis of Serum Lipid Components between Pre-Eclampsia Patients and Normal Pregnant Women[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 91-94.

Figures/Tables 5

References 15

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组别	n	年龄（岁）	BMI（kg/m²）	妊娠时间（d）
NC组	16	27.75±3.04	26.42±1.90	277.25±5.13
PE组	16	28.75±3.34	26.52±1.74	266.69±5.03
t		-0.886	-0.166	5.879
P		0.383	0.869	0.001

组别	n	年龄（岁）	BMI（kg/m²）	妊娠时间（d）
NC组	16	27.75±3.04	26.42±1.90	277.25±5.13
PE组	16	28.75±3.34	26.52±1.74	266.69±5.03
t		-0.886	-0.166	5.879
P		0.383	0.869	0.001

组别	n	PC	磷脂酰乙醇胺	PI	PA	PS	PG	LPC	LPE	LPI	LPA	LPS
NC组	16	1 205.87±178.10	129.34±22.50	30.57±8.52	0.40±0.10	0.95±0.06	0.21±0.07	71.97±14.58	2.49±0.84	0.90±0.14	0.38±0.13	0.01±0.00
PE组	16	1 149.72±153.37	121.34±18.44	27.66±3.50	0.42±0.12	0.94±0.12	0.20±0.04	77.83±17.77	2.22±0.47	0.84±0.17	0.37±0.11	0.01±0.00
t		0.956	1.099	1.262	-0.453	0.372	0.409	-1.019	1.115	1.029	0.213	1.056
P		0.347	0.280	0.217	0.654	0.713	0.685	0.317	0.274	0.312	0.833	0.299

组别	n	PC	磷脂酰乙醇胺	PI	PA	PS	PG	LPC	LPE	LPI	LPA	LPS
NC组	16	1 205.87±178.10	129.34±22.50	30.57±8.52	0.40±0.10	0.95±0.06	0.21±0.07	71.97±14.58	2.49±0.84	0.90±0.14	0.38±0.13	0.01±0.00
PE组	16	1 149.72±153.37	121.34±18.44	27.66±3.50	0.42±0.12	0.94±0.12	0.20±0.04	77.83±17.77	2.22±0.47	0.84±0.17	0.37±0.11	0.01±0.00
t		0.956	1.099	1.262	-0.453	0.372	0.409	-1.019	1.115	1.029	0.213	1.056
P		0.347	0.280	0.217	0.654	0.713	0.685	0.317	0.274	0.312	0.833	0.299

组别	n	SM	Sph	S1P	Cer	GluCer	GalCer	LacCer	Gb3	GM3
NC组	16	419.58±65.71	0.05±0.03	0.06±0.01	3.72±1.19	2.26±0.74	0.51±0.23	8.33±3.18	1.32±0.35	13.33±3.54
PE组	16	424.01±56.21	0.06±0.03	0.06±0.01	3.57±1.36	2.19±0.48	0.42±0.23	8.57±2.08	1.20±0.38	13.46±4.70
t		-0.205	1.000	-0.015	0.329	0.296	1.057	-0.259	0.907	-0.091
P		0.839	0.325	0.988	0.745	0.769	0.299	0.797	0.372	0.928